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Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota
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Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota
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Journal Article
Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota
2022
Overview
The gut microbiome is an important determinant in various diseases. Here we perform a cross-sectional study of Japanese adults and identify the
Blautia
genus, especially
B. wexlerae
, as a commensal bacterium that is inversely correlated with obesity and type 2 diabetes mellitus. Oral administration of
B. wexlerae
to mice induce metabolic changes and anti-inflammatory effects that decrease both high-fat diet–induced obesity and diabetes. The beneficial effects of
B. wexlerae
are correlated with unique amino-acid metabolism to produce S-adenosylmethionine, acetylcholine, and
l
-ornithine and carbohydrate metabolism resulting in the accumulation of amylopectin and production of succinate, lactate, and acetate, with simultaneous modification of the gut bacterial composition. These findings reveal unique regulatory pathways of host and microbial metabolism that may provide novel strategies in preventive and therapeutic approaches for metabolic disorders.
Here, the authors inversely associate
Blautia wexlerae
with obesity and type 2 diabetes mellitus in humans and further show that administration of
B. wexlerae
to mice decrease both high-fat diet–induced obesity and diabetes via modulating gut microbial metabolism.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/23
/ Adult
/ Animals
/ Blautia
/ Diabetes
/ Diabetes mellitus (non-insulin dependent)
/ Diabetes Mellitus, Type 2 - microbiology
/ Diabetes Mellitus, Type 2 - therapy
/ Diet
/ Diet, High-Fat - adverse effects
/ Gastrointestinal Microbiome - physiology
/ Humanities and Social Sciences
/ Humans
/ Japan
/ Mice
/ Obesity
/ Science
