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The non-coding RNA landscape of human hematopoiesis and leukemia

by Käbler, Sebastian , Huang, Yizhou , Kuchenbauer, Florian , Jammal, Razan , Jongen-Lavrencic, Mojca , Grasedieck, Sarah , Heckl, Dirk , Klusmann, Jan-Henning , Adams, Felix Ferdinand , Beck, Dominik , Schambach, Axel , Reimer, Christina , Wong, Jason W. H. , Maroz, Aliaksandra , Schmidt, Franziska , Shah, Anushi , Reinhardt, Dirk , Schwarzer, Adrian , Witte, Damian , Emmrich, Stephan , Ng, Michelle , Pimanda, John E.

in 631/337/384/2568 / 631/67/1990/283/1897 / Blood / Cell Lineage / Gene expression / Gene Expression Profiling / HEK293 Cells / Hematopoiesis / Hematopoietic system / Humanities and Social Sciences / Humans / Leukemia / Leukemia - metabolism / Leukemogenesis / multidisciplinary / Non-coding RNA / Regulators / Ribonucleic acid / RNA / RNA, Long Noncoding - physiology / RNA, Untranslated - metabolism / Science / Science (multidisciplinary) / Stem cells

2017

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The non-coding RNA landscape of human hematopoiesis and leukemia

2017

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2017

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Journal Article

The non-coding RNA landscape of human hematopoiesis and leukemia

Käbler, Sebastian,

Huang, Yizhou,

Kuchenbauer, Florian,

Jammal, Razan,

Jongen-Lavrencic, Mojca,

Grasedieck, Sarah,

Heckl, Dirk,

Klusmann, Jan-Henning,

Adams, Felix Ferdinand,

Beck, Dominik,

Schambach, Axel,

Reimer, Christina,

Wong, Jason W. H.,

Maroz, Aliaksandra,

Schmidt, Franziska,

Shah, Anushi,

Reinhardt, Dirk,

Schwarzer, Adrian,

Witte, Damian,

Emmrich, Stephan,

Ng, Michelle,

Pimanda, John E.

2017

Overview

Non-coding RNAs have emerged as crucial regulators of gene expression and cell fate decisions. However, their expression patterns and regulatory functions during normal and malignant human hematopoiesis are incompletely understood. Here we present a comprehensive resource defining the non-coding RNA landscape of the human hematopoietic system. Based on highly specific non-coding RNA expression portraits per blood cell population, we identify unique fingerprint non-coding RNAs—such as LINC00173 in granulocytes — and assign these to critical regulatory circuits involved in blood homeostasis. Following the incorporation of acute myeloid leukemia samples into the landscape, we further uncover prognostically relevant non-coding RNA stem cell signatures shared between acute myeloid leukemia blasts and healthy hematopoietic stem cells. Our findings highlight the importance of the non-coding transcriptome in the formation and maintenance of the human blood hierarchy. While micro-RNAs are known regulators of haematopoiesis and leukemogenesis, the role of long non-coding RNAs is less clear. Here the authors provide a non-coding RNA expression landscape of the human hematopoietic system, highlighting their role in the formation and maintenance of the human blood hierarchy.

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

631/337/384/2568

/ 631/67/1990/283/1897

/ Blood

/ Cell Lineage

/ Gene expression

/ Gene Expression Profiling

/ HEK293 Cells