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A sulfotransferase dosage-dependently regulates mouthpart polyphenism in the nematode Pristionchus pacificus
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A sulfotransferase dosage-dependently regulates mouthpart polyphenism in the nematode Pristionchus pacificus
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Journal Article
A sulfotransferase dosage-dependently regulates mouthpart polyphenism in the nematode Pristionchus pacificus
2018
Overview
Polyphenism, the extreme form of developmental plasticity, is the ability of a genotype to produce discrete morphologies matched to alternative environments. Because polyphenism is likely to be under switch-like molecular control, a comparative genetic approach could reveal the molecular targets of plasticity evolution. Here we report that the lineage-specific sulfotransferase SEUD-1, which responds to environmental cues, dosage-dependently regulates polyphenism of mouthparts in the nematode
Pristionchus pacificus
. SEUD-1 is expressed in cells producing dimorphic morphologies, thereby integrating an intercellular signalling mechanism at its ultimate target. Additionally, multiple alterations of
seud-1
support it as a potential target for plasticity evolution. First, a recent duplication of
seud-1
in a sister species reveals a direct correlation between genomic dosage and polyphenism threshold. Second, inbreeding to produce divergent polyphenism thresholds resulted in changes in transcriptional dosage of
seud-1
. Our study thus offers a genetic explanation for how plastic responses evolve.
Certain genotypes define developmental plasticity and discrete morphologies, but a mechanism as to how this arises is unclear. Here, the authors show that dosage-specific sulfotransferase (SEUD-1) expression specifies which mouthparts are expressed in the nematode
Pristionchus pacificus
, dependent on the environment.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 38/23
/ 38/35
/ 38/39
/ 38/70
/ 38/77
/ 38/88
/ 38/90
/ 38/91
/ 45
/ Animals
/ Animals, Genetically Modified
/ Dosage
/ Genes
/ Genomes
/ Genotype
/ Helminth Proteins - genetics
/ Helminth Proteins - metabolism
/ Humanities and Social Sciences
/ Mutation
/ Rhabditida - anatomy & histology
/ Science
/ Sulfotransferases - classification
/ Sulfotransferases - genetics
