Asset Details
Do you wish to reserve the book?
A novel atypical sperm centriole is functional during human fertilization
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
A novel atypical sperm centriole is functional during human fertilization
Do you wish to request the book?
A novel atypical sperm centriole is functional during human fertilization
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
A novel atypical sperm centriole is functional during human fertilization
2018
Overview
The inheritance of the centrosome during human fertilization remains mysterious. Here we show that the sperm centrosome contains, in addition to the known typical barrel-shaped centriole (the proximal centriole, PC), a surrounding matrix (pericentriolar material, PCM), and an atypical centriole (distal centriole, DC) composed of splayed microtubules surrounding previously undescribed rods of centriole luminal proteins. The sperm centrosome is remodeled by both reduction and enrichment of specific proteins and the formation of these rods during spermatogenesis. In vivo and in vitro investigations show that the flagellum-attached, atypical DC is capable of recruiting PCM, forming a daughter centriole, and localizing to the spindle pole during mitosis. Altogether, we show that the DC is compositionally and structurally remodeled into an atypical centriole, which functions as the zygote’s second centriole. These findings now provide novel avenues for diagnostics and therapeutic strategies for male infertility, and insights into early embryo developmental defects.
The two zygote centrioles are paternally inherited; however, their development is incompletely understood. Here, the authors show that the distal centriole is remodeled into an atypical centriole which functions as the zygote’s second centriole.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/28
/ 14/35
/ 14/63
/ Animals
/ Cattle
/ Cell Cycle Proteins - metabolism
/ Congenital Abnormalities - etiology
/ Embryonic Development - physiology
/ Female
/ Flagella
/ Heredity
/ Humanities and Social Sciences
/ Humans
/ Infertility, Male - etiology
/ Male
/ Microtubules - ultrastructure
/ Mitosis
/ Proteins
/ Rods
/ Science
/ Sperm
/ Spermatogenesis - physiology
