Asset Details
Do you wish to reserve the book?
Neuroinflammation after surgery: from mechanisms to therapeutic targets
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Neuroinflammation after surgery: from mechanisms to therapeutic targets
Do you wish to request the book?
Neuroinflammation after surgery: from mechanisms to therapeutic targets
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Neuroinflammation after surgery: from mechanisms to therapeutic targets
2020
Overview
Injury is a key driver of inflammation, a critical yet necessary response involving several mediators that is aimed at restoring tissue homeostasis. Inflammation in the central nervous system can be triggered by a variety of stimuli, some intrinsic to the brain and others arising from peripheral signals. Fine-tuned regulation of this response is crucial in a system that is vulnerable due to, for example, aging and ongoing neurodegeneration. In this context, seemingly harmless interventions like a common surgery to repair a broken limb can overwhelm the immune system and become the driver of further complications such as delirium and other perioperative neurocognitive disorders. Here, we discuss potential mechanisms by which the immune system affects the central nervous system after surgical trauma. Together, these neuroimmune interactions are becoming hallmarks of and potential therapeutic targets for multiple neurologic conditions, including those affecting the perioperative space.
Terrando and colleagues review key mechanisms related to postoperative inflammation and the implications for developing perioperative neurocognitive disorders, with a focus on neuroinflammation and key cellular targets affected by surgical trauma.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Aging
/ Animals
/ Biomedical and Life Sciences
/ Blood Coagulation Factors - genetics
/ Blood Coagulation Factors - metabolism
/ Blood-Brain Barrier - metabolism
/ Complement Activation - immunology
/ Complement System Proteins - immunology
/ Complement System Proteins - metabolism
/ Humans
/ Nervous System Diseases - diagnosis
/ Nervous System Diseases - etiology
/ Nervous System Diseases - metabolism
/ Nervous System Diseases - therapy
/ Surgery
/ Trauma
