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National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach
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National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach
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Journal Article
National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach
2012
Overview
We present a practical guide for the implementation of recently revised National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease (AD). Major revisions from previous consensus criteria are: (1) recognition that AD neuropathologic changes may occur in the apparent absence of cognitive impairment, (2) an “ABC” score for AD neuropathologic change that incorporates histopathologic assessments of amyloid β deposits (A), staging of neurofibrillary tangles (B), and scoring of neuritic plaques (C), and (3) more detailed approaches for assessing commonly co-morbid conditions such as Lewy body disease, vascular brain injury, hippocampal sclerosis, and TAR DNA binding protein (TDP)-43 immunoreactive inclusions. Recommendations also are made for the minimum sampling of brain, preferred staining methods with acceptable alternatives, reporting of results, and clinico-pathologic correlations.
Publisher
Springer-Verlag,Springer,Springer Nature B.V
Subject
/ Aging
/ Alzheimer Disease - pathology
/ Associations, institutions, etc
/ Brain
/ Cerebrovascular Disorders - classification
/ Cerebrovascular Disorders - pathology
/ Cerebrovascular Trauma - classification
/ Dementia
/ Deposits
/ Disease
/ DNA-Binding Proteins - metabolism
/ Humans
/ Injuries
/ Lewy Body Disease - classification
/ Lewy Body Disease - pathology
/ Medicine
/ National Institute on Aging (U.S.)
/ Plaques
/ Sampling
