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Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells
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Journal Article
Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells
2015
Overview
Furutachi
et al
. identified a slowly dividing subpopulation of embryonic progenitors that later gives rise to most adult neural stem cells (NSCs) in the subependymal zone. Moreover, they found that p57 is responsible for the slow cell cycle of this embryonic population and acts causally in the emergence of adult NSCs.
The mechanism by which adult neural stem cells (NSCs) are established during development is unclear. In this study, analysis of cell cycle progression by examining retention of a histone 2B (H2B)-GFP fusion protein revealed that, in a subset of mouse embryonic neural progenitor cells (NPCs), the cell cycle slows between embryonic day (E) 13.5 and E15.5 while other embryonic NPCs continue to divide rapidly. By allowing H2B-GFP expressed at E9.5 to become diluted in dividing cells until the young adult stage, we determined that a majority of NSCs in the young adult subependymal zone (SEZ) originated from these slowly dividing embryonic NPCs. The cyclin-dependent kinase inhibitor p57 is highly expressed in this embryonic subpopulation, and the deletion of
p57
impairs the emergence of adult NSCs. Our results suggest that a substantial fraction of adult SEZ NSCs is derived from a slowly dividing subpopulation of embryonic NPCs and identify p57 as a key factor in generating this embryonic origin of adult SEZ NSCs.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 14/19
/ 38
/ 38/1
/ Animal Genetics and Genomics
/ Animals
/ Cyclin-Dependent Kinase Inhibitor p57 - biosynthesis
/ Cyclin-Dependent Kinase Inhibitor p57 - genetics
/ Cyclin-Dependent Kinase Inhibitor p57 - physiology
/ Kinases
/ Mice
/ Nerve Tissue Proteins - biosynthesis
/ Nerve Tissue Proteins - genetics
/ Nerve Tissue Proteins - physiology
/ Neural Stem Cells - cytology
/ Neurons
