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Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis)
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Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis)
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Journal Article
Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis)
2010
Overview
The herbicide atrazine is one of the most commonly applied pesticides in the world. As a result, atrazine is the most commonly detected pesticide contaminant of ground, surface, and drinking water. Atrazine is also a potent endocrine disruptor that is active at low, ecologically relevant concentrations. Previous studies showed that atrazine adversely affects amphibian larval development. The present study demonstrates the reproductive consequences of atrazine exposure in adult amphibians. Atrazine-exposed males were both demasculinized (chemically castrated) and completely feminized as adults. Ten percent of the exposed genetic males developed into functional females that copulated with unexposed males and produced viable eggs. Atrazine-exposed males suffered from depressed testosterone, decreased breeding gland size, demasculinized/feminized laryngeal development, suppressed mating behavior, reduced spermatogenesis, and decreased fertility. These data are consistent with effects of atrazine observed in other vertebrate classes. The present findings exemplify the role that atrazine and other endocrine-disrupting pesticides likely play in global amphibian declines.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Animals
/ Anura
/ Atrazine
/ Breeding
/ endocrine-disrupting chemicals
/ Environmental Pollutants - toxicity
/ Female
/ Feminization - chemically induced
/ Feminization - physiopathology
/ Frogs
/ Male
/ males
/ Sex Differentiation - drug effects
/ Sexual Behavior, Animal - drug effects
/ Spermatogenesis - drug effects
/ Water
