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Evaluation of GeneXpert vanA/vanB in the early diagnosis of vancomycin-resistant enterococci infection
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Evaluation of GeneXpert vanA/vanB in the early diagnosis of vancomycin-resistant enterococci infection
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Journal Article
Evaluation of GeneXpert vanA/vanB in the early diagnosis of vancomycin-resistant enterococci infection
2021
Overview
Vancomycin-resistant enterococci infection is a worrying worldwide clinical problem. To evaluate the accuracy of GeneXpert vanA/vanB in the diagnosis of VRE, we conducted a systematic review in the study.
Experimental data were extracted from publications until May 03 2021 related to the diagnostic accuracy of GeneXpert vanA/vanB for VRE in PubMed, Embase, Web of Science and the Cochrane Library. The accuracy of GeneXpert vanA/vanB for VRE was evaluated using summary receiver to operate characteristic curve, pooled sensitivity, pooled specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio.
8 publications were divided into 3 groups according to two golden standard references, vanA and vanB group, vanA group, vanB group, including 6 researches, 5 researches and 5 researches, respectively. The pooled sensitivity and specificity of group vanA and vanB were 0.96 (95% CI, 0.93-0.98) and 0.90 (95% CI, 0.88-0.91) respectively. The DOR was 440.77 (95% CI, 37.92-5123.55). The pooled sensitivity and specificity of group vanA were 0.86 (95% CI, 0.81-0.90) and 0.99 (95% CI, 0.99-0.99) respectively, and those of group vanB were 0.85 (95% CI, 0.63-0.97) and 0.82 (95% CI, 0.80-0.83) respectively.
GeneXpert vanA/vanB can diagnose VRE with high-accuracy and shows greater accuracy in diagnosing vanA.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Anti-Bacterial Agents - pharmacology
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Bias
/ Carbon-Oxygen Ligases - genetics
/ Carbon-Oxygen Ligases - metabolism
/ Gram-Positive Bacterial Infections - diagnosis
/ Gram-Positive Bacterial Infections - microbiology
/ Humans
/ Medicine and Health Sciences
/ Research and Analysis Methods
/ Testing
/ Vancomycin-Resistant Enterococci - classification
/ Vancomycin-Resistant Enterococci - drug effects
/ Vancomycin-Resistant Enterococci - genetics
/ Vancomycin-Resistant Enterococci - isolation & purification
