Journal Article

Hallucinations Under Psychedelics and in the Schizophrenia Spectrum: An Interdisciplinary and Multiscale Comparison

Tehseen Noorani, David Dupuis, Yuliya Zaytseva, Katrin H. Preller, Pantelis Leptourgos, Michael Kometer, Martin Fortier-Davy, Renaud Jardri, Philip R. Corlett, Eva Kozáková, Robin L. Carhart-Harris, Adam L. Halberstadt, Flavie Waters, Frank Larøi

2020

Overview

Abstract The recent renaissance of psychedelic science has reignited interest in the similarity of drug-induced experiences to those more commonly observed in psychiatric contexts such as the schizophrenia-spectrum. This report from a multidisciplinary working group of the International Consortium on Hallucinations Research (ICHR) addresses this issue, putting special emphasis on hallucinatory experiences. We review evidence collected at different scales of understanding, from pharmacology to brain-imaging, phenomenology and anthropology, highlighting similarities and differences between hallucinations under psychedelics and in the schizophrenia-spectrum disorders. Finally, we attempt to integrate these findings using computational approaches and conclude with recommendations for future research.

• Publisher: Oxford University Press (OUP),Oxford University Press
• Subject: 10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics / 2.1 Biological and endogenous factors / 2.3 Psychological / 610 Medicine & health / Aetiology / Agonists / Bayesian / Behavior / Biomedical and Clinical Sciences / Brain Disorders / Brain research / Clinical psychology / Clinical sciences / computational / Hallucinations / Hallucinations - chemically induced / Hallucinations - diagnostic imaging / Hallucinations - etiology / Hallucinations - physiopathology / Hallucinogens / Hallucinogens - adverse effects / Human health and pathology / Humans / Interdisciplinary aspects / Life Sciences / LSD / Lysergic acid diethylamide / Medical and Health Sciences / Mental disorders / Mental Health / Nerve Net / Nerve Net - diagnostic imaging / Nerve Net - drug effects / Nerve Net - physiopathology / Neuroimaging / Neurosciences / Neurosciences & behavior / Neurosciences & comportement / Pharmacology / Pharmacology and Pharmaceutical Sciences / Psychedelic drugs / psychedelics / Psychiatrics and mental health / Psychiatry / Psychiatry and Mental Health / Psychology and Cognitive Sciences / Psychosis / Schizophrenia / Schizophrenia - complications / Schizophrenia - diagnostic imaging / Schizophrenia - physiopathology / Sciences sociales & comportementales, psychologie / Serious Mental Illness / seroto nin / serotonin / Social & behavioral sciences, psychology / social and economic factors / Theme: Hallucinations Research in a Time of Crisis