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Size and Flexibility Define the Inhibition of the H3N2 Influenza Endonuclease Enzyme by Calixnarenes

by Coleman, Anthony , Kim, Beomjoon , University of Tokyo [Tokyo] = Tōkyō teikoku daigaku (UTokyo) , Laboratory for Integrated Micro Mechatronics Systems (LIMMS) ; University of Tokyo [Tokyo] = Tōkyō teikoku daigaku (UTokyo)-Centre National de la Recherche Scientifique (CNRS) , Tauran, Yannick , Rhimi, Moez , MICrobiologie de l'ALImentation au Service de la Santé (MICALIS) ; Institut National de la Recherche Agronomique (INRA)-AgroParisTech , Perret, Florent , Cerón-Carrasco, José Pedro , Pérez-Sánchez, Horacio , Institut Supérieur de l'Electronique et du Numérique - Lille (ISEN-Lille) ; Institut supérieur de l'électronique et du numérique (ISEN)-Université catholique de Lille (UCL) , Collard, Dominique , Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS) ; Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon) ; Université de Lyon-Institut National des

in [CHIM.MATE]Chemical Sciences/Material chemistry / [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology / [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology / [SDV]Life Sciences [q-bio] / anti-viral activity / anti-viral activity;calix[n]arene;endonuclease;enzyme inhibitors;molecular docking;h3n2 virus / Aromatic compounds / Binding sites / calix[n]arene / Catalysis / Chemical Sciences / Cyclodextrins / Deoxyribonucleic acid / DNA / Drug resistance / Endonuclease / enzyme inhibitors / Enzymes / H3N2 virus / Infections / Influenza / Inhibition / Life Sciences / Ligands / Material chemistry / Molecular docking / Pandemics / Polyelectrolytes / Proteins / RM1-950 / Sulfates / Therapeutics. Pharmacology / Viruses / β-Cyclodextrin

2019

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Size and Flexibility Define the Inhibition of the H3N2 Influenza Endonuclease Enzyme by Calixnarenes

2019

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Size and Flexibility Define the Inhibition of the H3N2 Influenza Endonuclease Enzyme by Calixnarenes

2019

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Journal Article

Size and Flexibility Define the Inhibition of the H3N2 Influenza Endonuclease Enzyme by Calixnarenes

Coleman, Anthony,

Kim, Beomjoon,

University of Tokyo [Tokyo] = Tōkyō teikoku daigaku (UTokyo),

Laboratory for Integrated Micro Mechatronics Systems (LIMMS) ; University of Tokyo [Tokyo] = Tōkyō teikoku daigaku (UTokyo)-Centre National de la Recherche Scientifique (CNRS),

Tauran, Yannick,

Rhimi, Moez,

MICrobiologie de l'ALImentation au Service de la Santé (MICALIS) ; Institut National de la Recherche Agronomique (INRA)-AgroParisTech,

Perret, Florent,

Cerón-Carrasco, José Pedro,

Pérez-Sánchez, Horacio,

Institut Supérieur de l'Electronique et du Numérique - Lille (ISEN-Lille) ; Institut supérieur de l'électronique et du numérique (ISEN)-Université catholique de Lille (UCL),

Collard, Dominique,

Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS) ; Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon) ; Université de Lyon-Institut National des

2019

Overview

Inhibition of H3N2 influenza PA endonuclease activity by a panel of anionic calix[n]arenes and β-cyclodextrin sulfate has been studied. The joint experimental and theoretical results reveal that the larger, more flexible and highly water-soluble sulfonato-calix[n]arenes have high inhibitory activity, with para-sulfonato-calix[8]arene, SC8, having an IC50 value of 6.4 μM. Molecular docking calculations show the SC8 can interact at both the polyanion binding site and also the catalytic site of H3N2 influenza PA endonuclease

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Publisher

MDPI,CCSD,MDPI AG

Subject

[CHIM.MATE]Chemical Sciences/Material chemistry

/ [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology

/ [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology

/ [SDV]Life Sciences [q-bio]

/ anti-viral activity

/ anti-viral activity;calix[n]arene;endonuclease;enzyme inhibitors;molecular docking;h3n2 virus

/ Aromatic compounds