Asset Details
Do you wish to reserve the book?
α-cell glucokinase suppresses glucose-regulated glucagon secretion
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
α-cell glucokinase suppresses glucose-regulated glucagon secretion
Do you wish to request the book?
α-cell glucokinase suppresses glucose-regulated glucagon secretion
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
α-cell glucokinase suppresses glucose-regulated glucagon secretion
2018
Overview
Glucagon secretion by pancreatic α-cells is triggered by hypoglycemia and suppressed by high glucose levels; impaired suppression of glucagon secretion is a hallmark of both type 1 and type 2 diabetes. Here, we show that α-cell glucokinase (
Gck
) plays a role in the control of glucagon secretion. Using mice with α-cell-specific inactivation of
Gck
(
αGckKO
mice), we find that glucokinase is required for the glucose-dependent increase in intracellular ATP/ADP ratio and the closure of K
ATP
channels in α-cells and the suppression of glucagon secretion at euglycemic and hyperglycemic levels.
αGckKO
mice display hyperglucagonemia in the fed state, which is associated with increased hepatic gluconeogenic gene expression and hepatic glucose output capacity. In adult mice, fed hyperglucagonemia is further increased and glucose intolerance develops. Thus, glucokinase governs an α-cell metabolic pathway that suppresses secretion at or above normoglycemic levels; abnormal suppression of glucagon secretion deregulates hepatic glucose metabolism and, over time, induces a pre-diabetic phenotype.
Glucagon secretion is promoted during hypoglycemia and inhibited by increased glucose levels. Here, Basco et al. show that glucokinase suppresses glucose-regulated glucagon secretion by modulating the intracellular ATP/ADP ratio and the closure of K
ATP
channels in α-cells.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/10
/ 64/60
/ 82/51
/ 9/74
/ Adenosine Diphosphate - metabolism
/ Adenosine Triphosphate - metabolism
/ Animals
/ Diabetes mellitus (insulin dependent)
/ Diabetes mellitus (non-insulin dependent)
/ Female
/ Glucagon
/ Glucagon-Secreting Cells - metabolism
/ Glucagon-Secreting Cells - pathology
/ Glucose
/ Glucose Intolerance - genetics
/ Glucose Intolerance - metabolism
/ Glucose Intolerance - pathology
/ Humanities and Social Sciences
/ Male
/ Mice
/ Pancreas
/ Rodents
/ Science
