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A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation
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A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation
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A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation
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Journal Article
A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation
2020
Overview
Virus neutralization remains the gold standard for determining antibody efficacy. Therefore, a high-throughput assay to measure SARS-CoV-2 neutralizing antibodies is urgently needed for COVID-19 serodiagnosis, convalescent plasma therapy, and vaccine development. Here, we report on a fluorescence-based SARS-CoV-2 neutralization assay that detects SARS-CoV-2 neutralizing antibodies in COVID-19 patient specimens and yields comparable results to plaque reduction neutralizing assay, the gold standard of serological testing. The fluorescence-based neutralization assay is specific to measure COVID-19 neutralizing antibodies without cross reacting with patient specimens with other viral, bacterial, or parasitic infections. Collectively, our approach offers a rapid platform that can be scaled to screen people for antibody protection from COVID-19, a key parameter necessary to safely reopen local communities.
Neutralizing antibody titers in SARS-CoV-2 infected or vaccinated people are an important measure for vaccine development and public health decision-making. Here, the authors develop a fluorescence based SARS-CoV-2 assay to determine neutralizing antibody titers in COVID-19 patient sera in a high throughput set-up.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 49
/ Animals
/ Antibodies, Neutralizing - immunology
/ Assaying
/ Betacoronavirus - immunology
/ Clinical Laboratory Techniques - methods
/ Coronavirus Infections - diagnosis
/ Coronavirus Infections - immunology
/ Coronavirus Infections - prevention & control
/ Coronavirus Infections - virology
/ COVID-19
/ High-Throughput Screening Assays - methods
/ Humanities and Social Sciences
/ Humans
/ Pandemics - prevention & control
/ Pneumonia, Viral - diagnosis
/ Pneumonia, Viral - prevention & control
/ Science
/ Severe acute respiratory syndrome coronavirus 2
/ Vaccines
/ Viruses
