Journal Article

Office blood pressure versus ambulatory blood pressure measurement in childhood obesity

Groothoff, Jaap W., van der Heijden, Laila B, Janse, Arieke J, Feskens, Edith JM

2023

Overview

Background The prevalence of obesity-related co-morbidities is rising parallel to the childhood obesity epidemic. High blood pressure (BP), as one of these co-morbidities, is detected nowadays at increasingly younger ages. The diagnosis of elevated BP and hypertension, especially in the childhood population, presents a challenge to clinicians. The added value of ambulatory blood pressure measurement (ABPM) in relation to office blood pressure (OBP) measurements in obese children is unclear. Furthermore, it is unknown how many overweight and obese children have an abnormal ABPM pattern. In this study we evaluated ABPM patterns in a population of overweight and obese children and adolescents, and compared these patterns with regular OBP measurements. Methods In this cross-sectional study in overweight or obese children and adolescents aged 4–17 years who were referred to secondary pediatric obesity care in a large general hospital in The Netherlands, OBP was measured during a regular outpatient clinic visit. Additionally, all participants underwent a 24-hour ABPM on a regular week-day. Outcome measures were OBP, mean ambulatory SBP and DBP, BP load (percentage of readings above the ambulatory 95th blood pressure percentiles), ambulatory BP pattern (normal BP, white-coat hypertension, elevated BP, masked hypertension, ambulatory hypertension), and BP dipping. Results We included 82 children aged 4–17 years. They had a mean BMI Z-score of 3.3 (standard deviation 0.6). Using ABPM, 54.9% of the children were normotensive (95% confidence interval 44.1–65.2), 26.8% had elevated BP, 9.8% ambulatory hypertension, 3.7% masked hypertension, and 4.9% white-coat hypertension. An isolated night-time BP load > 25% was detected in almost a quarter of the children. 40% of the participants lacked physiologic nocturnal systolic BP dipping. In the group of children with normal OBP, 22.2% turned out to have either elevated BP or masked hypertension on ABPM. Conclusions In this study a high prevalence of abnormal ABPM patterns in overweight or obese children and adolescents was detected. Additionally, OBP poorly correlated with the child’s actual ABPM pattern. Herewith, we emphasized the usefulness of ABPM as an important diagnostic tool in this population.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adolescent / Analysis / Blood pressure / Blood Pressure - physiology / Blood Pressure Monitoring, Ambulatory / Care and treatment / Child / Childhood / Cholesterol / Clinics / Comorbidity / Complications and side effects / Cross-Sectional Studies / Diabetes / Diagnosis / Glucose / High density lipoprotein / Humans / Hypertension / Hypertension - diagnosis / Hypertension - epidemiology / Hypertension - etiology / Insulin resistance / Internal Medicine / Masked hypertension / Masked Hypertension - complications / Measurement / Medical diagnosis / Medicine / Medicine & Public Health / Metabolic syndrome / Obesity / Obesity in children / Outpatient care facilities / Overweight / Overweight - complications / Pediatric obesity / Pediatric Obesity - complications / Pediatric Obesity - diagnosis / Pediatric Obesity - epidemiology / Pediatrics / Prevalence studies (Epidemiology) / Services / Teenagers / Triglycerides / White coat hypertension / White Coat Hypertension - complications / White Coat Hypertension - diagnosis / White Coat Hypertension - epidemiology