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Novel genotypes of Coxiella burnetii circulating in rats in Yunnan Province, China
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Novel genotypes of Coxiella burnetii circulating in rats in Yunnan Province, China
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Journal Article
Novel genotypes of Coxiella burnetii circulating in rats in Yunnan Province, China
2022
Overview
Background
Coxiella burnetii
(Cb) is the causative agent of the zoonotic disease Q fever which is distributed worldwide. Molecular typing of Cb strains is essential to find out the infectious source and prevent Q fever outbreaks, but there has been a lack of typing data for Cb strains in China. The aim of this study was to investigate the genotypes of Cb strains in wild rats in Yunnan Province, China.
Results
Eighty-six wild rats (
Rattus flavipectus
) were collected in Yunnan Province and 8 of the 86 liver samples from the wild rats were positive in Cb-specific quantitative PCR (qPCR). The Cb strains from the 8 rats were then typed into 3 genotypes using 10-spacer multispacer sequence typing (MST), and 2 of the 3 genotypes were recognized as novel ones. Moreover, the Cb strains in the wild rats were all identified as genotype 1 using 6-loci multilocus variable number of tandem repeat analysis (MLVA).
Conclusions
This is the first report of genotypic diversity of Cb strains from wild rats in China. Further studies are needed to explore the presence of more genotypes and to associate the genotypes circulating in the wildlife-livestock interaction with those causing human disease to further expand on the epidemiological aspects of the pathogen.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ China
/ Coxiella burnetii - genetics
/ Genotype
/ Identification and classification
/ Liver
/ Medicine
/ MLVA
/ Molecular Typing - veterinary
/ MST
/ Mutation
/ Q fever
/ quantitative polymerase chain reaction
/ Rats
/ Rattus
/ Rodent Diseases - epidemiology
/ Veterinary Medicine/Veterinary Science
/ Wildlife
/ Zoology
/ Zoonoses
