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Moving tuberculosis vaccines from theory to practice
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Moving tuberculosis vaccines from theory to practice
Moving tuberculosis vaccines from theory to practice
Journal Article

Moving tuberculosis vaccines from theory to practice

2019
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Overview
Tuberculosis (TB) vaccine research has reached a unique point in time. Breakthrough findings in both the basic immunology of Mycobacterium tuberculosis infection and the clinical development of TB vaccines suggest, for the first time since the discovery of the Mycobacterium bovis bacillus Calmette–Guérin (BCG) vaccine more than a century ago, that a novel, efficacious TB vaccine is imminent. Here, we review recent data in the light of our current understanding of the immunology of TB infection and discuss the identification of biomarkers for vaccine efficacy and the next steps in the quest for an efficacious vaccine that can control the global TB epidemic.Vaccine trials against Mycobacterium tuberculosis (Mtb) are showing encouraging results. This Review discusses current Mtb vaccine design in the light of new insights into the immunology of tuberculosis infection.