Asset Details
Do you wish to reserve the book?
Co-exposure to inhaled tungsten particles and low-dose gamma rays: neurotoxicological outcome in rats
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Co-exposure to inhaled tungsten particles and low-dose gamma rays: neurotoxicological outcome in rats
Do you wish to request the book?
Co-exposure to inhaled tungsten particles and low-dose gamma rays: neurotoxicological outcome in rats
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Co-exposure to inhaled tungsten particles and low-dose gamma rays: neurotoxicological outcome in rats
2025
Overview
Throughout their lives, individuals are exposed to various pollutants, potentially including co-exposure to radiological and chemical stressors. Yet, existing literature about these combinations is scarce. We selected tungsten and ionizing radiations. Tungsten is an emerging contaminant present as aerosolized particles in several scenarios, potentially concurrently with low-dose irradiation, causing a co-exposure. The cerebral toxicity of this co-exposure was studied after 24 h and 28 days in the frontal cortex and olfactory bulb of male Sprague–Dawley rats exposed to gamma irradiation (50 mGy) and/or inhalation of tungsten particles aerosol (80 mg.m
−3
). Co-exposure triggered significant effects more frequently than single stressors. Observed effects were associated with oxidative status changes, notably via NRF2 nuclear translocation, and modulation of pro-inflammatory cytokines (IL1β, TNFα). A reduction in cortical microglial density suggested a cellular migration toward the olfactory bulb and could contribute to the occurrence of a neuronal suffering phenotype. The effects persisted at 28 days and were brain structure specific. Biodistribution of tungsten showed that both local and systemic effects might be involved. Our results suggest interaction between our stressors, causing cerebral toxicity, and prove the importance of multi-stressor studies to improve risks evaluation in toxicology and radiation protection, as single stressors might wrongly be deemed safe.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Animals
/ Exposure
/ Frontal Lobe - radiation effects
/ Gamma Rays - adverse effects
/ Humanities and Social Sciences
/ Inhalation Exposure - adverse effects
/ Male
/ Microglia - radiation effects
/ Olfactory Bulb - drug effects
/ Olfactory Bulb - radiation effects
/ Oxidative Stress - drug effects
/ Oxidative Stress - radiation effects
/ Rats
/ Science
/ Toxicity
/ Tungsten
