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The molecular biology of peritoneal metastatic disease
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Journal Article
The molecular biology of peritoneal metastatic disease
2023
Overview
Peritoneal metastases are a common form of tumor cell dissemination in gastrointestinal malignancies. Peritoneal metastatic disease (PMD) is associated with severe morbidity and resistance to currently employed therapies. Given the distinct route of dissemination compared with distant organ metastases, and the unique microenvironment of the peritoneal cavity, specific tumor cell characteristics are needed for the development of PMD. In this review, we provide an overview of the known histopathological, genomic, and transcriptomic features of PMD. We find that cancers representing the mesenchymal subtype are strongly associated with PMD in various malignancies. Furthermore, we discuss the peritoneal niche in which the metastatic cancer cells reside, including the critical role of the peritoneal immune system. Altogether, we show that PMD should be regarded as a distinct disease entity, that requires tailored treatment strategies.
Graphical Abstract
In this review, S. Bootsma, M. Bijlsma, and L. Vermeulen provide an overview of the histopathological, genomic, and transcriptomic features of peritoneal metastases and argue that peritoneal metastatic disease should be considered a distinct disease entity.
Publisher
Nature Publishing Group UK,EMBO Press,John Wiley and Sons Inc,Springer Nature
