Asset Details
Do you wish to reserve the book?
Signatures of negative selection in the genetic architecture of human complex traits
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Signatures of negative selection in the genetic architecture of human complex traits
Do you wish to request the book?
Signatures of negative selection in the genetic architecture of human complex traits
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Signatures of negative selection in the genetic architecture of human complex traits
2018
Overview
We develop a Bayesian mixed linear model that simultaneously estimates single-nucleotide polymorphism (SNP)-based heritability, polygenicity (proportion of SNPs with nonzero effects), and the relationship between SNP effect size and minor allele frequency for complex traits in conventionally unrelated individuals using genome-wide SNP data. We apply the method to 28 complex traits in the UK Biobank data (
N
= 126,752) and show that on average, 6% of SNPs have nonzero effects, which in total explain 22% of phenotypic variance. We detect significant (
P
< 0.05/28) signatures of natural selection in the genetic architecture of 23 traits, including reproductive, cardiovascular, and anthropometric traits, as well as educational attainment. The significant estimates of the relationship between effect size and minor allele frequency in complex traits are consistent with a model of negative (or purifying) selection, as confirmed by forward simulation. We conclude that negative selection acts pervasively on the genetic variants associated with human complex traits.
BayesS estimates SNP-based heritability, polygenicity, and the relationship between effect size and minor allele frequency using genome-wide SNP data. Applying BayesS to UK Biobank data identifies signatures of natural selection for 23 complex traits.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 45
/ 45/43
/ Alleles
/ Analysis
/ Animal Genetics and Genomics
/ Biomedical and Life Sciences
/ Genome-Wide Association Study - methods
/ Genomes
/ Genomics
/ Genotype
/ Humans
/ Methods
/ Multifactorial Inheritance - genetics
/ Mutation
/ Polymorphism, Single Nucleotide - genetics
/ Quantitative Trait, Heritable
/ Selection, Genetic - genetics
/ Single nucleotide polymorphisms
