Journal Article

Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

Vermeulen, Sita H, Mayordomo, Jose I, Thorleifsson, Gudmar, Vineis, Paolo, Thorgeirsson, Thorgeir E, Jonsson, Eirikur, Kumar, Rajiv, Swinkels, Dorine W, Mouy, Magali, Campagna, Marcello, Gurzau, Eugene, Koppova, Kvetoslava, Geller, Frank, Jakobsdottir, Margret, Rafnar, Thorunn, Bergthorsson, Jon T, Stefansson, Kari, Hulsbergen-van de Kaa, Christina A, Lindblom, Annika, Ploeg, Martine, Aben, Katja K H, Cornel, Erik B, Vergunst, Henk, Buntinx, Frank, Sigurdsson, Asgeir, Sacerdote, Carlotta, Porru, Stefano, Gudmundsson, Julius, Stacey, Simon N, de Verdier, Petra, Gulcher, Jeffrey R, Geirsson, Gudmundur, Kristinsson, Kari T, Matullo, Giuseppe, Thorsteinsdottir, Unnur, Nikulasson, Sigfus, Rudnai, Peter, Snorradottir, Steinunn, Kristjansson, Baldvin, Kong, Augustine, Saez, Berta, Sanchez, Manuel, Valdivia, Gabriel, Golka, Klaus, Sulem, Patrick, Guarrera, Simonetta, Knowles, Margaret A, Witjes, J Alfred, Kiltie, Anne E, Bishop, D Timothy, Ryk, Charlotta, Arici, Cecilia, Petursdottir, Vigdis, Fletcher, Tony, Gudjonsson, Sigurjon A, Zeegers, Maurice P, Thorlacius, Steinunn, Steineck, Gunnar, Kiemeney, Lamber

2008

Overview

Kari Stefansson and colleagues report results of a genome-wide association study for urinary bladder cancer. The strongest association was with a variant on 8q24, located 30 kb upstream of MYC in a haplotype block distinct from previously reported 8q24 cancer risk variants. We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 × 10 −12 ). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 × 10 −7 ).

• Publisher: Nature Publishing Group US,Nature Publishing Group
• Subject: Adult / Aged / Aged, 80 and over / Agriculture / Animal Genetics and Genomics / Apoptosis / Base Sequence / Biological and medical sciences / Biomedical and Life Sciences / Biomedicine / Bladder cancer / Cancer / Cancer Research / Case-Control Studies / Chromosomes, Human, Pair 3 - genetics / Chromosomes, Human, Pair 8 - genetics / Classical genetics, quantitative genetics, hybrids / Diagnosis / Female / Fundamental and applied biological sciences. Psychology / Gene Function / Genetic aspects / Genetic Markers / Genetic Predisposition to Disease / Genetics / Genetics of eukaryotes. Biological and molecular evolution / Health aspects / Human Genetics / Humans / letter / Linkage Disequilibrium - genetics / Male / Medical research / Medical sciences / Methods, theories and miscellaneous / Middle Aged / Mutation - genetics / Nephrology. Urinary tract diseases / Oncogenes / Physiological aspects / Population / Risk factors / Sample size / Single nucleotide polymorphisms / Smoking / Tumors / Tumors of the urinary system / Urinary bladder / Urinary Bladder Neoplasms - genetics / Urinary system involvement in other diseases. Miscellaneous / Urinary tract. Prostate gland