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Intestinal microbiota development and gestational age in preterm neonates
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Intestinal microbiota development and gestational age in preterm neonates
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Journal Article
Intestinal microbiota development and gestational age in preterm neonates
2018
Overview
The intestinal microbiota is an important contributor to the health of preterm infants, and may be destabilized by a number of environmental factors and treatment modalities. How to promote the development of a healthy microbiota in preterm infants is largely unknown. We collected fecal samples from 45 breastfed preterm very low birth weight (birth weight < 1500 g) infants from birth until 60 days postnatal age to characterize the intestinal microbiota development during the first weeks of life in preterm infants. Fecal microbiota composition was determined by 16S rRNA amplicon sequencing. The main driver of microbiota development was gestational age; antibiotic use had strong but temporary effects and birth mode had little influence. Microbiota development proceeded in four phases indicated by the dominance of
Staphylococcus, Enterococcus, Enterobacter
, and finally
Bifidobacterium
. The
Enterococcus
phase was only observed among the extremely premature infants and appeared to delay the microbiota succession. The results indicate that hospitalized preterm infants receiving breast milk may develop a normal microbiota resembling that of term infants.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Age
/ Anti-Bacterial Agents - therapeutic use
/ Bifidobacterium - classification
/ Bifidobacterium - drug effects
/ Bifidobacterium - isolation & purification
/ Enterobacter - classification
/ Enterobacter - isolation & purification
/ Enterococcus - classification
/ Enterococcus - isolation & purification
/ Female
/ Gastrointestinal Microbiome - drug effects
/ Gastrointestinal Microbiome - physiology
/ Humanities and Social Sciences
/ Humans
/ Infant
/ Infant, Very Low Birth Weight
/ Infants
/ Laboratorium voor Microbiologie
/ Male
/ Neonates
/ RNA, Ribosomal, 16S - genetics
/ rRNA 16S
/ Science
/ Staphylococcus - classification
/ Staphylococcus - drug effects
/ Staphylococcus - isolation & purification
/ VLAG
/ WIMEK
