Journal Article

Reduced tactile acuity in chronic low back pain is linked with structural neuroplasticity in primary somatosensory cortex and is modulated by acupuncture therapy

Gerber, Jessica, Lee, Jeungchan, Kaptchuk, Ted J., Wasan, Ajay D., Mawla, Ishtiaq, Chan, Suk-Tak, Edwards, Robert R., Kim, Hyungjun, Kong, Jian, Gollub, Randy L., Napadow, Vitaly, Walker, Kathryn, Ortiz, Ana, Kim, Jieun, Loggia, Marco L., Rosen, Bruce R.

2020

Overview

Prior studies have shown that patients suffering from chronic Low Back Pain (cLBP) have impaired somatosensory processing including reduced tactile acuity, i.e. reduced ability to resolve fine spatial details with the perception of touch. The central mechanism(s) underlying reduced tactile acuity are unknown but may include changes in specific brain circuitries (e.g. neuroplasticity in the primary somatosensory cortex, S1). Furthermore, little is known about the linkage between changes in tactile acuity and the amelioration of cLBP by somatically-directed therapeutic interventions, such as acupuncture. In this longitudinal neuroimaging study, we evaluated healthy control adults (HC, N ​= ​50) and a large sample of cLBP patients (N ​= ​102) with structural brain imaging (T1-weighted MRI for Voxel-Based Morphometry, VBM; Diffusion Tensor Imaging, DTI) and tactile acuity testing using two-point discrimination threshold (2PDT) over the lower back (site of pain) and finger (control) locations. Patients were evaluated at baseline and following a 4-week course of acupuncture, with patients randomized to either verum acupuncture, two different forms of sham acupuncture (designed with or without somatosensory afference), or no-intervention usual care control. At baseline, cLBP patients demonstrated reduced acuity (greater 2PDT, P ​= ​0.01) over the low back, but not finger (P ​= ​0.29) locations compared to HC, suggesting that chronic pain affects tactile acuity specifically at body regions encoding the experience of clinical pain. At baseline, Gray Matter Volume (GMV) was elevated and Fractional Anisotropy (FA) was reduced, respectively, in the S1-back region of cLBP patients compared to controls (P ​< ​0.05). GMV in cLBP correlated with greater 2PDT-back scores (ρ ​= ​0.27, P ​= ​0.02). Following verum acupuncture, tactile acuity over the back was improved (reduced 2PDT) and greater improvements were associated with reduced S1-back GMV (ρ ​= ​0.52, P ​= ​0.03) and increased S1-back adjacent white matter FA (ρ ​= ​−0.56, P ​= ​0.01). These associations were not seen for non-verum control interventions. Thus, S1 neuroplasticity in cLBP is linked with deficits in tactile acuity and, following acupuncture therapy, may represent early mechanistic changes in somatosensory processing that track with improved tactile acuity.

• Publisher: Elsevier Inc,Elsevier Limited,Elsevier
• Subject: Acuity / Acupuncture / Acupuncture Therapy - methods / Adolescent / Adult / Agnosia - etiology / Agnosia - physiopathology / Agnosia - therapy / Anisotropy / Back pain / Carpal tunnel syndrome / Chronic pain / Contraindications / Diffusion Tensor Imaging / Discrimination, Psychological / Female / Gray Matter - diagnostic imaging / Gray Matter - physiopathology / Health care / Humans / Intervention / Longitudinal Studies / Low back pain / Low Back Pain - diagnostic imaging / Low Back Pain - physiopathology / Low Back Pain - therapy / Magnetic resonance imaging / Male / Medical imaging / Middle Aged / Morphometry / Nervous system / Neuroimaging / Neuronal Plasticity / Neuroplasticity / Primary sensory cortex / Psychomotor Performance / Sensory perception / Sensory Thresholds / Single-Blind Method / Somatosensory cortex / Somatosensory Cortex - physiopathology / Spatial discrimination / Substantia alba / Substantia grisea / Tactile acuity / Tactile discrimination / Therapeutic applications / Touch Perception / Treatment Outcome / Two-point discrimination threshold / Young Adult