Asset Details
Do you wish to reserve the book?
Stage-specific control of early B cell development by the transcription factor Ikaros
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Stage-specific control of early B cell development by the transcription factor Ikaros
Do you wish to request the book?
Stage-specific control of early B cell development by the transcription factor Ikaros
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Stage-specific control of early B cell development by the transcription factor Ikaros
2014
Overview
The transcription factor Ikaros is required for lymphopoiesis. Busslinger and colleagues show Ikaros positively regulates genes encoding pre-BCR signal transducers and thereby promotes pro-B to pre-B cell progression and proliferation.
The transcription factor Ikaros is an essential regulator of lymphopoiesis. Here we studied its B cell–specific function by conditional inactivation of the gene encoding Ikaros (
Ikzf1
) in pro-B cells. B cell development was arrested at an aberrant 'pro-B cell' stage characterized by increased cell adhesion and loss of signaling via the pre-B cell signaling complex (pre-BCR). Ikaros activated genes encoding signal transducers of the pre-BCR and repressed genes involved in the downregulation of pre-BCR signaling and upregulation of the integrin signaling pathway. Unexpectedly, derepression of expression of the transcription factor Aiolos did not compensate for the loss of Ikaros in pro-B cells. Ikaros induced or suppressed active chromatin at regulatory elements of activated or repressed target genes. Notably, binding of Ikaros and expression of its target genes were dynamically regulated at distinct stages of early B lymphopoiesis.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Adhesion
/ Animals
/ B cells
/ Cell Differentiation - immunology
/ Chromatin Immunoprecipitation
/ Gene Expression Regulation - immunology
/ Ikaros Transcription Factor - immunology
/ Ikaros Transcription Factor - metabolism
/ Mice
/ Precursor Cells, B-Lymphoid - cytology
/ Precursor Cells, B-Lymphoid - immunology
We currently cannot retrieve any items related to this title. Kindly check back at a later time.