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Journal Article
Circadian rhythms, sleep, and metabolism
2011
Overview
The discovery of the genetic basis for circadian rhythms has expanded our knowledge of the temporal organization of behavior and physiology. The observations that the circadian gene network is present in most living organisms from eubacteria to humans, that most cells and tissues express autonomous clocks, and that disruption of clock genes results in metabolic dysregulation have revealed interactions between metabolism and circadian rhythms at neural, molecular, and cellular levels. A major challenge remains in understanding the interplay between brain and peripheral clocks and in determining how these interactions promote energy homeostasis across the sleep-wake cycle. In this Review, we evaluate how investigation of molecular timing may create new opportunities to understand and develop therapies for obesity and diabetes.
Publisher
American Society for Clinical Investigation
Subject
/ Circadian Rhythm - drug effects
/ Circadian Rhythm - physiology
/ Circadian Rhythm - radiation effects
/ Circadian Rhythm Signaling Peptides and Proteins - genetics
/ Circadian Rhythm Signaling Peptides and Proteins - physiology
/ Diabetes Mellitus, Type 2 - physiopathology
/ Diet
/ Dietary Fats - adverse effects
/ Energy
/ Energy Metabolism - physiology
/ Genes
/ Humans
/ Intracellular Signaling Peptides and Proteins - physiology
/ Kinases
/ Light
/ Mice
/ Obesity
/ Orexins
/ Review
