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Volatile vs Total intravenous Anaesthesia for major non-cardiac surgery: a pragmatic randomised triaL (VITAL)
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Volatile vs Total intravenous Anaesthesia for major non-cardiac surgery: a pragmatic randomised triaL (VITAL)
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Journal Article
Volatile vs Total intravenous Anaesthesia for major non-cardiac surgery: a pragmatic randomised triaL (VITAL)
2024
Overview
Background
Improving outcomes after surgery is a major public health research priority for patients, clinicians and the NHS. The greatest burden of perioperative complications, mortality and healthcare costs lies amongst the population of patients aged over 50 years who undergo major non-cardiac surgery. The Volatile vs Total Intravenous Anaesthesia for major non-cardiac surgery (VITAL) trial specifically examines the effect of anaesthetic technique on key patient outcomes: quality of recovery after surgery (quality of recovery after anaesthesia, patient satisfaction and major post-operative complications), survival and patient safety.
Methods
A multi-centre pragmatic efficient randomised trial with health economic evaluation comparing total intravenous anaesthesia with volatile-based anaesthesia in adults (aged 50 and over) undergoing elective major non-cardiac surgery under general anaesthesia.
Discussion
Given the very large number of patients exposed to general anaesthesia every year, even small differences in outcome between the two techniques could result in substantial excess harm. Results from the VITAL trial will ensure patients can benefit from the very safest anaesthesia care, promoting an early return home, reducing healthcare costs and maximising the health benefits of surgical treatments.
Trial registration
ISRCTN62903453. September 09, 2021.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Anesthesia, General - adverse effects
/ Anesthesia, General - economics
/ Anesthesia, General - methods
/ Anesthesia, Inhalation - adverse effects
/ Anesthesia, Inhalation - economics
/ Anesthesia, Inhalation - methods
/ Anesthesia, Intravenous - adverse effects
/ Anesthesia, Intravenous - economics
/ Anesthesia, Intravenous - methods
/ Cancer
/ Elective Surgical Procedures
/ Female
/ Humans
/ Male
/ Medicine
/ Multicenter Studies as Topic
/ Post-operative complications
/ Postoperative Complications - economics
/ Postoperative Complications - etiology
/ Postoperative Complications - prevention & control
/ Pragmatic Clinical Trials as Topic
