Asset Details
Do you wish to reserve the book?
Electrical and synaptic integration of glioma into neural circuits
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Electrical and synaptic integration of glioma into neural circuits
Do you wish to request the book?
Electrical and synaptic integration of glioma into neural circuits
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Electrical and synaptic integration of glioma into neural circuits
2019
Overview
High-grade gliomas are lethal brain cancers whose progression is robustly regulated by neuronal activity. Activity-regulated release of growth factors promotes glioma growth, but this alone is insufficient to explain the effect that neuronal activity exerts on glioma progression. Here we show that neuron and glioma interactions include electrochemical communication through bona fide AMPA receptor-dependent neuron–glioma synapses. Neuronal activity also evokes non-synaptic activity-dependent potassium currents that are amplified by gap junction-mediated tumour interconnections, forming an electrically coupled network. Depolarization of glioma membranes assessed by in vivo optogenetics promotes proliferation, whereas pharmacologically or genetically blocking electrochemical signalling inhibits the growth of glioma xenografts and extends mouse survival. Emphasizing the positive feedback mechanisms by which gliomas increase neuronal excitability and thus activity-regulated glioma growth, human intraoperative electrocorticography demonstrates increased cortical excitability in the glioma-infiltrated brain. Together, these findings indicate that synaptic and electrical integration into neural circuits promotes glioma progression.
Neurons form synapses onto glioma cells, and depolarization of glioma membranes promotes glioma growth in vivo, whereas blocking electrochemical signalling blocks tumour growth.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/51
/ 14/19
/ 14/28
/ 14/69
/ 38/91
/ Animals
/ Biopsy
/ Brain
/ Circuits
/ Cortex
/ Editing
/ Electrical Synapses - pathology
/ Electrophysiological Phenomena
/ Gene Expression Regulation, Neoplastic
/ Genetics
/ Glioma
/ Humanities and Social Sciences
/ Humans
/ Mice
/ Neurons
/ Optics
/ Principal components analysis
/ Science
/ Synapses
/ Tumors
/ α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid
/ α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
