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Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
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Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
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Journal Article
Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
2019
Overview
Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor prognosis and rising incidence. Late detection and a particularly aggressive biology are the major challenges which determine therapeutic failure. In this review, we present the current status and the recent advances in PDAC treatment together with the biological and immunological hallmarks of this cancer entity. On this basis, we discuss new concepts combining distinct treatment modalities in order to improve therapeutic efficacy and clinical outcome – with a specific focus on protocols involving radio(chemo)therapeutic approaches.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ Analysis
/ B cells
/ Biomedical and Life Sciences
/ Carcinoma, Pancreatic Ductal - pathology
/ Carcinoma, Pancreatic Ductal - therapy
/ Dose intensified radiation therapy for the treatment of pancreatic cancer
/ Humans
/ Imaging
/ implementation and prerequisites
/ Oncology
/ Pancreatic Neoplasms - pathology
/ Pancreatic Neoplasms - therapy
/ Radiation Biology and Molecular Radiation Oncology
/ Review
/ Surgery
