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Cyclic AMP–regulated exocytosis of Escherichia coli from infected bladder epithelial cells
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Cyclic AMP–regulated exocytosis of Escherichia coli from infected bladder epithelial cells
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Journal Article
Cyclic AMP–regulated exocytosis of Escherichia coli from infected bladder epithelial cells
2007
Overview
The superficial bladder epithelium is a powerful barrier to urine and also serves as a regulator of bladder volume, which is achieved by apical exocytosis of specialized fusiform vesicles during distension of the bladder. We report that type 1 fimbriated uropathogenic
Escherichia coli
(UPEC) circumvents the bladder barrier by harboring in these Rab27b/CD63-positive and cAMP-regulatable fusiform vesicles within bladder epithelial cells (BECs). Incorporation of UPEC into BEC fusiform compartments enabled bacteria to escape elimination during voiding and to re-emerge in the urine as the bladder distended. Notably, treatment of UPEC-infected mice with a drug that increases intracellular cAMP and induces exocytosis of fusiform vesicles reduced the number of intracellular
E. coli
.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Bacterial Adhesion - drug effects
/ Bacterial Adhesion - physiology
/ Biomedical and Life Sciences
/ E coli
/ Escherichia coli - drug effects
/ Escherichia coli - physiology
/ Escherichia coli Infections - prevention & control
/ Humans
/ letter
/ Mice
/ Rodents
/ Urinary Bladder - drug effects
/ Urinary Bladder - microbiology
/ Urinary Tract Infections - prevention & control
/ Urine
