Journal Article

Hierarchical and nonhierarchical features of the mouse visual cortical network

Knoblauch, Kenneth, ANR-17-HBPR-0003,CORTICITY,Etudes comparatives des circuits corticaux chez la Souris, le PNH et l'homme, ANR-17-NEUC-0004,A2P2MC,Architectural Principles and Predictive Modeling of the Mammalian Connectome, D’souza, Rinaldo, D, Meier, Andrew, M, Wang, Quanxin, Ji, Weiqing, Burkhalter, Andreas, ANR-11-LABX-0042,CORTEX,Construction, Fonction Cognitive et Réhabilitation du Cerveau, ANR-15-CE32-0016,CORNET,Intégration des processus ascendants et descendants du cortex chez le marmouset et le macaque, Institut cellule souche et cerveau / Stem Cell and Brain Research Institute (SBRI) ; Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Kennedy, Henry, ANR-11-IDEX-0007,Avenir L.S.E.,PROJET AVENIR LYON SAINT-ETIENNE, Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon

2022

Overview

Abstract Neocortical computations underlying vision are performed by a distributed network of functionally specialized areas. Mouse visual cortex, a dense interareal network that exhibits hierarchical properties, comprises subnetworks interconnecting distinct processing streams. To determine the layout of the mouse visual hierarchy, we have evaluated the laminar patterns formed by interareal axonal projections originating in each of ten areas. Reciprocally connected pairs of areas exhibit feedforward/feedback relationships consistent with a hierarchical organization. Beta regression analyses, which estimate a continuous hierarchical distance measure, indicate that the network comprises multiple nonhierarchical circuits embedded in a hierarchical organization of overlapping levels. Single-unit recordings in anaesthetized mice show that receptive field sizes are generally consistent with the hierarchy, with the ventral stream exhibiting a stricter hierarchy than the dorsal stream. Together, the results provide an anatomical metric for hierarchical distance, and reveal both hierarchical and nonhierarchical motifs in mouse visual cortex.

• Publisher: Nature Publishing Group,CCSD,Nature Publishing Group UK,Nature Portfolio
• Subject: 14/1 / 14/34 / 14/63 / 631/378/116 / 631/378/2613 / 631/378/3920 / 64/60 / 82/51 / Animals / Computational Biology / Computer networks / Female / Humanities and Social Sciences / Laboratories / Life Sciences / Male / Mice / Mice, Inbred C57BL / Monkeys & apes / Mouse devices / multidisciplinary / Neurons and Cognition / Neurosciences / Receptive field / Regression analysis / Science / Science (multidisciplinary) / Visual cortex / Visual Cortex - pathology / Visual Cortex - physiology / Visual pathways / Visual Pathways - pathology / Visual Pathways - physiology