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Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
by
John, Laurence
, Lynen, Lut
, Maartens, Gary
, Seyler, Catherine
, Meintjes, Graeme
, van der Loeff, Maarten Schim
, Reiss, Peter
, Worodria, William
, Gilks, Charles
, Murdoch, David
, Wilkinson, Robert J
, Janoff, Edward N
, French, Martyn A
, Elliott, Julian H
, Lawn, Stephen D
, Colebunders, Robert
, Scano, Fabio
in
AIDS-Related Opportunistic Infections - drug therapy
/ AIDS-Related Opportunistic Infections - immunology
/ AIDS-Related Opportunistic Infections - microbiology
/ Anti-HIV Agents - therapeutic use
/ Antiretroviral agents
/ Antitubercular Agents - therapeutic use
/ Bacterial diseases
/ Biological and medical sciences
/ General aspects
/ Health Resources
/ HIV Infections - complications
/ HIV Infections - drug therapy
/ HIV Infections - immunology
/ Human bacterial diseases
/ Humans
/ Immune Reconstitution Inflammatory Syndrome - diagnosis
/ Immune Reconstitution Inflammatory Syndrome - immunology
/ Immune Reconstitution Inflammatory Syndrome - physiopathology
/ Immunopathology
/ Infectious Disease
/ Infectious diseases
/ Male
/ Medical sciences
/ Middle Aged
/ Poverty
/ Public health
/ Tuberculosis
/ Tuberculosis and atypical mycobacterial infections
/ Tuberculosis, Pulmonary - drug therapy
/ Tuberculosis, Pulmonary - immunology
/ Tuberculosis, Pulmonary - physiopathology
2008
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Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
by
John, Laurence
, Lynen, Lut
, Maartens, Gary
, Seyler, Catherine
, Meintjes, Graeme
, van der Loeff, Maarten Schim
, Reiss, Peter
, Worodria, William
, Gilks, Charles
, Murdoch, David
, Wilkinson, Robert J
, Janoff, Edward N
, French, Martyn A
, Elliott, Julian H
, Lawn, Stephen D
, Colebunders, Robert
, Scano, Fabio
in
AIDS-Related Opportunistic Infections - drug therapy
/ AIDS-Related Opportunistic Infections - immunology
/ AIDS-Related Opportunistic Infections - microbiology
/ Anti-HIV Agents - therapeutic use
/ Antiretroviral agents
/ Antitubercular Agents - therapeutic use
/ Bacterial diseases
/ Biological and medical sciences
/ General aspects
/ Health Resources
/ HIV Infections - complications
/ HIV Infections - drug therapy
/ HIV Infections - immunology
/ Human bacterial diseases
/ Humans
/ Immune Reconstitution Inflammatory Syndrome - diagnosis
/ Immune Reconstitution Inflammatory Syndrome - immunology
/ Immune Reconstitution Inflammatory Syndrome - physiopathology
/ Immunopathology
/ Infectious Disease
/ Infectious diseases
/ Male
/ Medical sciences
/ Middle Aged
/ Poverty
/ Public health
/ Tuberculosis
/ Tuberculosis and atypical mycobacterial infections
/ Tuberculosis, Pulmonary - drug therapy
/ Tuberculosis, Pulmonary - immunology
/ Tuberculosis, Pulmonary - physiopathology
2008
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Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
by
John, Laurence
, Lynen, Lut
, Maartens, Gary
, Seyler, Catherine
, Meintjes, Graeme
, van der Loeff, Maarten Schim
, Reiss, Peter
, Worodria, William
, Gilks, Charles
, Murdoch, David
, Wilkinson, Robert J
, Janoff, Edward N
, French, Martyn A
, Elliott, Julian H
, Lawn, Stephen D
, Colebunders, Robert
, Scano, Fabio
in
AIDS-Related Opportunistic Infections - drug therapy
/ AIDS-Related Opportunistic Infections - immunology
/ AIDS-Related Opportunistic Infections - microbiology
/ Anti-HIV Agents - therapeutic use
/ Antiretroviral agents
/ Antitubercular Agents - therapeutic use
/ Bacterial diseases
/ Biological and medical sciences
/ General aspects
/ Health Resources
/ HIV Infections - complications
/ HIV Infections - drug therapy
/ HIV Infections - immunology
/ Human bacterial diseases
/ Humans
/ Immune Reconstitution Inflammatory Syndrome - diagnosis
/ Immune Reconstitution Inflammatory Syndrome - immunology
/ Immune Reconstitution Inflammatory Syndrome - physiopathology
/ Immunopathology
/ Infectious Disease
/ Infectious diseases
/ Male
/ Medical sciences
/ Middle Aged
/ Poverty
/ Public health
/ Tuberculosis
/ Tuberculosis and atypical mycobacterial infections
/ Tuberculosis, Pulmonary - drug therapy
/ Tuberculosis, Pulmonary - immunology
/ Tuberculosis, Pulmonary - physiopathology
2008
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Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
Journal Article
Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
2008
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Overview
The immune reconstitution inflammatory syndrome (IRIS) has emerged as an important early complication of antiretroviral therapy (ART) in resource-limited settings, especially in patients with tuberculosis. However, there are no consensus case definitions for IRIS or tuberculosis-associated IRIS. Moreover, previously proposed case definitions are not readily applicable in settings where laboratory resources are limited. As a result, existing studies on tuberculosis-associated IRIS have used a variety of non-standardised general case definitions. To rectify this problem, around 100 researchers, including microbiologists, immunologists, clinicians, epidemiologists, clinical trialists, and public-health specialists from 16 countries met in Kampala, Uganda, in November, 2006. At this meeting, consensus case definitions for paradoxical tuberculosis-associated IRIS, ART-associated tuberculosis, and unmasking tuberculosis-associated IRIS were derived, which can be used in high-income and resource-limited settings. It is envisaged that these definitions could be used by clinicians and researchers in a variety of settings to promote standardisation and comparability of data.
Publisher
Elsevier Ltd,Lancet Publishing Group,Elsevier Limited
Subject
AIDS-Related Opportunistic Infections - drug therapy
/ AIDS-Related Opportunistic Infections - immunology
/ AIDS-Related Opportunistic Infections - microbiology
/ Anti-HIV Agents - therapeutic use
/ Antitubercular Agents - therapeutic use
/ Biological and medical sciences
/ HIV Infections - complications
/ HIV Infections - drug therapy
/ Humans
/ Immune Reconstitution Inflammatory Syndrome - diagnosis
/ Immune Reconstitution Inflammatory Syndrome - immunology
/ Immune Reconstitution Inflammatory Syndrome - physiopathology
/ Male
/ Poverty
/ Tuberculosis and atypical mycobacterial infections
/ Tuberculosis, Pulmonary - drug therapy
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