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The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue
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The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue
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Journal Article
The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue
2019
Overview
Light-sheet microscopy is an ideal technique for imaging large cleared samples; however, the community is still lacking instruments capable of producing volumetric images of centimeter-sized cleared samples with near-isotropic resolution within minutes. Here, we introduce the mesoscale selective plane-illumination microscopy initiative, an open-hardware project for building and operating a light-sheet microscope that addresses these challenges and is compatible with any type of cleared or expanded sample (www.mesospim.org).
