Journal Article

Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression

Cooke Bailey, Jessica N., Landers, John, Ruddle, Jonathan B., Agar, Ashish, Hewitt, Alex W., Casson, Robert J., Graham, Stuart L., Han, Xikun, Law, Matthew H., Jonas, Jost B., Kinzy, Tyler G., Best, Stephen, Pasquale, Louis R., Marshall, Henry, Cree, Angela Jane, van Duijn, Cornelia M., Montgomery, Grant W., Pasutto, Francesca, Siggs, Owen, Mitchell, Paul, Hammond, Christopher J., Mills, Richard A., Viswanathan, Ananth C., Khawaja, Anthony P., Burdon, Kathryn P., Ong, Jue-Sheng, An, Jiyuan, Zhou, Tiger, White, Andrew J. R., Willoughby, Colin E., Wojciechowski, Robert, Galanopoulos, Anna, Khaw, Peng Tee, Souzeau, Emmanuelle, Klaver, Caroline C. W., Haines, Jonathan L., Craig, Jamie E., Vallabh, Neeru A., Ridge, Bronwyn, Martin, Nicholas G., Wiggs, Janey L., Hassall, Mark, Hysi, Pirro G., Sivaprasad, Sobha, Vitart, Veronique, Gharahkhani, Puya, Mackey, David A., Healey, Paul R., Vincent, Andrea L., Foster, Paul J., Igo, Robert P., Lotery, Andrew J., Aung, Tin, Hoehn, Rene, MacGregor, Stuart, Andrew, Nicholas H., Goldberg, Ivan, Radford-Smith, Graham, Qassim, Ayub

2020

Overview

Glaucoma, a disease characterized by progressive optic nerve degeneration, can be prevented through timely diagnosis and treatment. We characterize optic nerve photographs of 67,040 UK Biobank participants and use a multitrait genetic model to identify risk loci for glaucoma. A glaucoma polygenic risk score (PRS) enables effective risk stratification in unselected glaucoma cases and modifies penetrance of the MYOC variant encoding p.Gln368Ter, the most common glaucoma-associated myocilin variant. In the unselected glaucoma population, individuals in the top PRS decile reach an absolute risk for glaucoma 10 years earlier than the bottom decile and are at 15-fold increased risk of developing advanced glaucoma (top 10% versus remaining 90%, odds ratio = 4.20). The PRS predicts glaucoma progression in prospectively monitored, early manifest glaucoma cases ( P  = 0.004) and surgical intervention in advanced disease ( P  = 3.6 × 10 − 6 ). This glaucoma PRS will facilitate the development of a personalized approach for earlier treatment of high-risk individuals, with less intensive monitoring and treatment being possible for lower-risk groups. Multitrait genome-wide analysis of glaucoma and related phenotypes identifies new risk loci and enables development of a polygenic risk score to predict disease susceptibility and key clinical outcomes.

• Publisher: Nature Publishing Group US,Nature Publishing Group
• Subject: 45/43 / 631/208/205 / 692/308/2056 / 692/308/575 / Agriculture / Animal Genetics and Genomics / Australia / Biobanks / Biomedical and Life Sciences / Biomedicine / Cancer Research / Case-Control Studies / Cytoskeletal Proteins - genetics / Datasets / Degeneration / Development and progression / Diagnosis / Disease Progression / Disease susceptibility / Eye Proteins - genetics / Gene Function / Genes / Genetic aspects / Genetic Predisposition to Disease / Genome-Wide Association Study / Genomes / Genomics / Glaucoma / Glaucoma - etiology / Glaucoma - genetics / Glaucoma - surgery / Glycoproteins - genetics / Human Genetics / Humans / Intraocular Pressure - genetics / Loci / Medical colleges / Medical research / Medicine, Experimental / Morphology / Multifactorial Inheritance / Odds Ratio / Optic nerve / Optic Nerve - physiology / Penetrance / Polygenic inheritance / Polymorphism, Single Nucleotide / Risk / Risk groups / Trabeculectomy - adverse effects / United Kingdom / United States