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Does azithromycin given to women in labour decrease ocular bacterial infection in neonates? A double-blind, randomized trial
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Does azithromycin given to women in labour decrease ocular bacterial infection in neonates? A double-blind, randomized trial
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Journal Article
Does azithromycin given to women in labour decrease ocular bacterial infection in neonates? A double-blind, randomized trial
2017
Overview
Background
Vertical transmission can result in neonatal infection and disease. Reducing the transmission of bacterial pathogens from mother to infant may be an effective means of preventing neonatal infection, including bacterial conjunctivitis.
Methods
In a double-blind, randomized trial, we assessed the effect of administering a single dose of oral azithromycin to women in labour on bacterial colonization of the neonate. A reduction in purulent neonatal conjunctivitis was a secondary objective of the trial. Ocular samples were collected from the lower fornix of infants presenting with clinical signs of purulent conjunctivitis during the first eight weeks of life. Incidence of purulent conjunctivitis was compared between trial arms. Bacterial infection was assessed using PCR and incidence of purulent conjunctivitis due to bacteria was also compared between arms.
Results
Forty of 843 infants (4.7%) presented clinical signs of purulent conjunctivitis. No significant difference in incidence of purulent conjunctivitis was seen between azithromycin and placebo arms [4.3% (18/419) versus 5.2% (22/424), OR = 0.82, 95% CI (0.44,1.54),
p
= 0.628].
S. aureus
was the most commonly identified pathogen, detected in 38% of cases. Incidence of purulent-conjunctivitis due to bacterial infection was lower in the azithromycin arm [1.2% (5/419) versus 3.8% (16/424), OR = 0.31, 95% CI (0.12–0.82),
p
= 0.025)]. The incidence of gram-positive bacteria was also lower in the azithromycin arm [1.0% (4/419) versus 3.3% (14/424), OR = 0.28, 95%CI (0.10–0.82),
p
= 0.029].
Conclusions
Oral azithromycin given to women during labour may have the potential to reduce the incidence of bacterial neonatal conjunctivitis.
Trial registration
ClinicalTrials.gov, identifier
NCT01800942
, registration date 26 Feb 2013.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
/ Adult
/ Azithromycin - therapeutic use
/ Bacteria
/ Bacteria - isolation & purification
/ Bacterial and fungal diseases
/ Conjunctivitis, Bacterial - epidemiology
/ Conjunctivitis, Bacterial - microbiology
/ Conjunctivitis, Bacterial - prevention & control
/ DNA, Bacterial - isolation & purification
/ Female
/ Humans
/ Infectious Disease Transmission, Vertical - prevention & control
/ Labour
/ Male
/ Medicine
/ Neonate
/ Staphylococcus aureus - genetics
