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Brain Organoids: Studying Human Brain Development and Diseases in a Dish
by
Wen, Zhexing
, Xu, Jie
in
Alzheimer's disease
/ Analysis
/ Apoptosis
/ Brain
/ Brain architecture
/ Brain stem
/ Cell cycle
/ CRISPR
/ High-throughput screening
/ Hypoxia
/ Medical research
/ Medicine, Experimental
/ Microcephaly
/ Mutation
/ Nervous system diseases
/ Neurodevelopmental disorders
/ Neurogenesis
/ Neurological diseases
/ Neurological disorders
/ Neurons
/ Organoids
/ Review
/ Severe acute respiratory syndrome coronavirus 2
/ Stem cells
2021
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Brain Organoids: Studying Human Brain Development and Diseases in a Dish
by
Wen, Zhexing
, Xu, Jie
in
Alzheimer's disease
/ Analysis
/ Apoptosis
/ Brain
/ Brain architecture
/ Brain stem
/ Cell cycle
/ CRISPR
/ High-throughput screening
/ Hypoxia
/ Medical research
/ Medicine, Experimental
/ Microcephaly
/ Mutation
/ Nervous system diseases
/ Neurodevelopmental disorders
/ Neurogenesis
/ Neurological diseases
/ Neurological disorders
/ Neurons
/ Organoids
/ Review
/ Severe acute respiratory syndrome coronavirus 2
/ Stem cells
2021
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Do you wish to request the book?
Brain Organoids: Studying Human Brain Development and Diseases in a Dish
by
Wen, Zhexing
, Xu, Jie
in
Alzheimer's disease
/ Analysis
/ Apoptosis
/ Brain
/ Brain architecture
/ Brain stem
/ Cell cycle
/ CRISPR
/ High-throughput screening
/ Hypoxia
/ Medical research
/ Medicine, Experimental
/ Microcephaly
/ Mutation
/ Nervous system diseases
/ Neurodevelopmental disorders
/ Neurogenesis
/ Neurological diseases
/ Neurological disorders
/ Neurons
/ Organoids
/ Review
/ Severe acute respiratory syndrome coronavirus 2
/ Stem cells
2021
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Brain Organoids: Studying Human Brain Development and Diseases in a Dish
Journal Article
Brain Organoids: Studying Human Brain Development and Diseases in a Dish
2021
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Overview
With the rapid development of stem cell technology, the advent of three-dimensional (3D) cultured brain organoids has opened a new avenue for studying human neurodevelopment and neurological disorders. Brain organoids are stem-cell-derived 3D suspension cultures that self-assemble into an organized structure with cell types and cytoarchitectures recapitulating the developing brain. In recent years, brain organoids have been utilized in various aspects, ranging from basic biology studies, to disease modeling, and high-throughput screening of pharmaceutical compounds. In this review, we overview the establishment and development of brain organoid technology, its recent progress, and translational applications, as well as existing limitations and future directions.
Publisher
Hindawi,John Wiley & Sons, Inc,Wiley
Subject
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