Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Topography of cancer-associated immune cells in human solid tumors

by Horning, Marcel , Hoffmeister, Michael , Weis, Cleo-Aron , Schott, Sarah , Utikal, Jochen , Zörnig, Inka , Halama, Niels , Bankhead, Peter , Jäger, Dirk , Suarez-Carmona, Meggy , Marx, Alexander , Charoentong, Pornpimol , Chang-Claude, Jenny , Ferber, Dyke , Brenner, Herrmann , Hirsch, Daniela , Gaiser, Timo , Herpel, Esther , Kather, Jakob Nikolas , Kel, Ivan

in Biological markers / biomarker / Biomarkers / Cancer / Cancer Biology / cancer immunology / Cancer research / CD163 antigen / CD8 antigen / Cell Count / Cluster Analysis / Cohort Studies / Cold / Colorectal cancer / Colorectal carcinoma / digital pathology / Epidemiology / Hospitals / human / Human health sciences / Humans / Image Processing, Computer-Assisted / Immunohistochemistry / immunology / Immunology and Inflammation / Immunotherapy / Inflammation / Lymphocytes / Lymphocytes - pathology / Macrophages / Macrophages - pathology / Medical research / Metastases / Myeloid cells / Neoplasms - immunology / Oncologie / Oncology / Pathology / Phenotype / Prognosis / Research centers / Sciences de la santé humaine / Solid tumors / Topography / Tumors

2018

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Topography of cancer-associated immune cells in human solid tumors

2018

Confirm

Do you wish to request the book?

Topography of cancer-associated immune cells in human solid tumors

2018

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Topography of cancer-associated immune cells in human solid tumors

Horning, Marcel,

Hoffmeister, Michael,

Weis, Cleo-Aron,

Schott, Sarah,

Utikal, Jochen,

Zörnig, Inka,

Halama, Niels,

Bankhead, Peter,

Jäger, Dirk,

Suarez-Carmona, Meggy,

Marx, Alexander,

Charoentong, Pornpimol,

Chang-Claude, Jenny,

Ferber, Dyke,

Brenner, Herrmann,

Hirsch, Daniela,

Gaiser, Timo,

Herpel, Esther,

Kather, Jakob Nikolas,

Kel, Ivan

2018

Overview

Lymphoid and myeloid cells are abundant in the tumor microenvironment, can be quantified by immunohistochemistry and shape the disease course of human solid tumors. Yet, there is no comprehensive understanding of spatial immune infiltration patterns (‘topography’) across cancer entities and across various immune cell types. In this study, we systematically measure the topography of multiple immune cell types in 965 histological tissue slides from N = 177 patients in a pan-cancer cohort. We provide a definition of inflamed (‘hot’), non-inflamed (‘cold’) and immune excluded patterns and investigate how these patterns differ between immune cell types and between cancer types. In an independent cohort of N = 287 colorectal cancer patients, we show that hot, cold and excluded topographies for effector lymphocytes (CD8) and tumor-associated macrophages (CD163) alone are not prognostic, but that a bivariate classification system can stratify patients. Our study adds evidence to consider immune topographies as biomarkers for patients with solid tumors.

Share this book

Add to My Shelf

Publisher

eLife Science Publications, Ltd,eLife Sciences Publications Ltd,eLife Sciences Publications,eLife Sciences Publications, Ltd

Subject

/ Cancer