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Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation

by Okamoto, S , Carreras, E , Savani, B N , Masszi, T , Pagliuca, A , Peters, C , Dalle, J-H , Petersen, F B , Ciceri, F , Dignan, F , Richardson, P G , Malard, F , Nagler, A , Ruutu, T , Michallet, M , Corbacioglu, S , Arat, M , Aljurf, M , Baron, F , Huynh, A , Yakoub-Agha, I , Blaise, D , Aerts, E , Fukuda, T , Alaskar, A S , Mohty, M , Wallhult, E , NiChonghaile, M , Bader, P , Abecassis, M , Duarte, R F , Bazarbachi, A

in 692/1807 / 692/699 / Adult / Biomarkers / Bone marrow / Cell Biology / Complications and side effects / Diagnosis / Early Diagnosis / Evaluation / Hematology / Hematopoietic stem cell transplantation / Hematopoietic Stem Cell Transplantation - adverse effects / Hepatic Veno-Occlusive Disease - diagnosis / Hepatic Veno-Occlusive Disease - etiology / Hepatic Veno-Occlusive Disease - therapy / Human health sciences / Humans / Hématologie / Internal Medicine / Medicine / Medicine & Public Health / Methods / Practice guidelines (Medicine) / Preventive medicine / Public Health / Risk Factors / Sciences de la santé humaine / Sensitivity and Specificity / Severity of Illness Index / Special Report / Stem cell transplantation / Stem Cells / Vascular diseases

2016

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Journal Article

Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation

Okamoto, S,

Carreras, E,

Savani, B N,

Masszi, T,

Pagliuca, A,

Peters, C,

Dalle, J-H,

Petersen, F B,

Ciceri, F,

Dignan, F,

Richardson, P G,

Malard, F,

Nagler, A,

Ruutu, T,

Michallet, M,

Corbacioglu, S,

Arat, M,

Aljurf, M,

Baron, F,

Huynh, A,

Yakoub-Agha, I,

Blaise, D,

Aerts, E,

Fukuda, T,

Alaskar, A S,

Mohty, M,

Wallhult, E,

NiChonghaile, M,

Bader, P,

Abecassis, M,

Duarte, R F,

Bazarbachi, A

2016

Overview

Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (>80%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation.

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature

Subject

692/1807

/ 692/699

/ Adult

/ Biomarkers

/ Bone marrow

/ Cell Biology

/ Complications and side effects