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Integration of molecular profiles in a longitudinal wellness profiling cohort

by von Feilitzen, Kalle , Karlsson, Max J. , Jansson, Per-Anders , Schwenk, Jochen M. , Boulund, Fredrik , Moritz, Thomas , Zhang, Cheng , Tremaroli, Valentina , Koistinen, Ina Schuppe , Chen, Yang , Danielsson, Hanna , Fagerberg, Linn , Angerås, Oskar , Brodin, Petter , Bäckhed, Fredrik , Tebani, Abdellah , Bergström, Göran , Lakshmikanth, Tadepally , Olin, Axel , Neiman, Maja , Zhong, Wen , Mardinoglu, Adil , Lee, Sunjae , Kjellqvist, Sanela , Nilsson, Peter , Uhlen, Mathias , Dodig-Crnković, Tea , Huss, Mikael , Engstrand, Lars , Hellström, Cecilia , Arif, Muhammad , Mikes, Jaromir , Stenlund, Hans , Edfors, Fredrik , Forsström, Björn , Gummesson, Anders , Olsson, Lisa M. , Odeberg, Jacob

in 38 / 38/91 / 631/114 / 631/114/2401 / 692/4017 / 82/1 / 82/58 / 82/80 / Aged / Annan klinisk medicin / Autoantibodies / Biotechnology / Bioteknologi / Blood / Cardiology and Cardiovascular Disease / Cohort Studies / Composition / Female / General Biochemistry / General Chemistry / General Physics and Astronomy / genetics / Genetics and Molecular Biology / Healthy Aging / Healthy Aging - genetics / Healthy Aging - metabolism / Healthy Volunteers / Humanities and Social Sciences / Humans / Immune system / Intestinal microflora / Kardiologi och kardiovaskulära sjukdomar / Lipidomics / Longitudinal Studies / Male / metabolism / Metabolome / Metabolomics / Microbiota / Middle Aged / multidisciplinary / Other Clinical Medicine / Precision Medicine / Prospective Studies / Proteome / Proteome - metabolism / Proteomes / Proteomics / Science / Science (multidisciplinary) / Stability / Sweden / Transcriptome

2020

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2020

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Journal Article

Integration of molecular profiles in a longitudinal wellness profiling cohort

von Feilitzen, Kalle,

Karlsson, Max J.,

Jansson, Per-Anders,

Schwenk, Jochen M.,

Boulund, Fredrik,

Moritz, Thomas,

Zhang, Cheng,

Tremaroli, Valentina,

Koistinen, Ina Schuppe,

Chen, Yang,

Danielsson, Hanna,

Fagerberg, Linn,

Angerås, Oskar,

Brodin, Petter,

Bäckhed, Fredrik,

Tebani, Abdellah,

Bergström, Göran,

Lakshmikanth, Tadepally,

Olin, Axel,

Neiman, Maja,

Zhong, Wen,

Mardinoglu, Adil,

Lee, Sunjae,

Kjellqvist, Sanela,

Nilsson, Peter,

Uhlen, Mathias,

Dodig-Crnković, Tea,

Huss, Mikael,

Engstrand, Lars,

Hellström, Cecilia,

Arif, Muhammad,

Mikes, Jaromir,

Stenlund, Hans,

Edfors, Fredrik,

Forsström, Björn,

Gummesson, Anders,

Olsson, Lisa M.,

Odeberg, Jacob

2020

Overview

An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies and immune cell profiling, complemented with gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine. An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, the authors sample a longitudinal wellness cohort and analyse blood molecular profiles as well as gut microbiota composition.

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

/ 38/91

/ 631/114

/ 631/114/2401

/ 692/4017

/ 82/1

/ 82/58

/ 82/80