Journal Article

Effects of desflurane and sevoflurane on somatosensory-evoked and motor-evoked potential monitoring during neurosurgery: a randomized controlled trial

Zhang, Yulong, Zhou, Qijun, Yao, Yuting, Xiang, Bingbing, Wang, Lu, Yuan, Feng, Chen, Rui, Jiao, Shulan

2021

Overview

Background Better protection can be provided during neurosurgery due to the establishment of somatosensory-evoked potential (SEP) and motor-evoked potential (MEP) monitoring technologies. However, some studies have showed that inhaled halogenated anesthetics have a significant impact on neurophysiological monitoring. Methods A total of 40 consecutive patients undergoing neurosurgery were randomly assigned to two groups receiving inhaled anesthetics, either desflurane or sevoflurane. Multiples levels (concentrations of 0.3, 0.6 and 0.9) of anesthetics were administered at minimum alveolar concentration (MAC), and then the latencies and amplitudes of SEPs and MEPs were recorded. Results SEP and MEP signals were well preserved in patients who underwent neurosurgery under general anesthesia supplemented with desflurane or sevoflurane at concentrations of 0.3, 0.6 and 0.9 MAC. In each desflurane or sevoflurane group, the amplitudes of SEPs and MEPs decreased and the latencies of SEPs were prolonged significantly as the MAC increased ( P  < 0.05). The SEP latencies of both the upper and lower limbs in the desflurane group were significantly longer, and the SEP amplitudes were significantly lower than those in the sevoflurane group ( P  < 0.05). The MEP amplitudes in the desflurane group were significantly lower than those in the sevoflurane group ( P  < 0.05), only the amplitudes of the upper limbs at 0.3 MAC did not vary significantly. Conclusions SEPs and MEPs were inhibited in a dose-dependent manner by both desflurane and sevoflurane. At the same MAC concentration, desflurane appeared to have a stronger inhibitory effect than sevoflurane. All patients studied had normal neurological examination findings, hence, these results may not be applicable to patients with preexisting deficits. Trial registration The study registered on the Chinese Clinical Trial Registry ( www.chictr.org.cn ), Clinical Trials identifier ChiCTR2100045504 (18/04/2021).

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adult / Alveoli / Analysis / Anesthesia / Anesthesiology / Anesthetics / Anesthetics, Inhalation - pharmacology / Blood pressure / Clinical trials / Critical Care Medicine / Desflurane - pharmacology / Desflurane Sevoflurane / Electrodes / Emergency Medicine / Evoked Potentials, Motor - drug effects / Evoked Potentials, Somatosensory - drug effects / Female / General anesthesia / Heart rate / Humans / Intensive / Internal Medicine / Limbs / Male / Medical research / Medicine / Medicine & Public Health / Medicine, Experimental / Middle Aged / Monitoring / Monitoring, Intraoperative - methods / Motor evoked potentials / Nervous system / Neurophysiology / Neurosurgery / Neurosurgical Procedures / Patients / Pharmaceutical industry / Sevoflurane / Sevoflurane - pharmacology / Somatosensory evoked potentials / Surgery