Asset Details
Do you wish to reserve the book?
Acid sensing by the Drosophila olfactory system
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Acid sensing by the Drosophila olfactory system
Do you wish to request the book?
Acid sensing by the Drosophila olfactory system
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Acid sensing by the Drosophila olfactory system
2010
Overview
Sensing the odour of acid
We are familiar with the unpleasant and often irritating odour associated with acids, but whereas acid receptors are known to underlie the detection of sour tastes, no acid-sensing neurons were known in the olfactory system. Greg Suh and colleagues now report the identification of such neurons in the olfactory system of the fruitfly,
Drosophila melanogaster
. Acid sensing also requires the transmembrane protein IR64a to be expressed in those neurons. IR64a is not sufficient by itself to determine acid recognition, but its requirement is the first known function for a member of the recently discovered ionotropic receptor family of putative odorant receptors.
Acid sensing has so far been demonstrated in the gustatory system only. Now, fruitfly olfactory sensory neurons selectively activated by acidic compounds have been identified. Acid sensing also requires the transmembrane protein IR64a, expressed in those neurons as well as neurons involved in the detection of non acidic odorants. Although the IR64a protein isn't sufficient by itself to determine acid recognition, the requirement for IR64a in acid recognition is the first function for a member of this recently discovered family of putative odorant receptors — the ionotropic receptor family.
The odour of acids has a distinct quality that is perceived as sharp, pungent and often irritating
1
. How acidity is sensed and translated into an appropriate behavioural response is poorly understood. Here we describe a functionally segregated population of olfactory sensory neurons in the fruitfly,
Drosophila melanogaster
, that are highly selective for acidity. These olfactory sensory neurons express IR64a, a member of the recently identified ionotropic receptor (IR) family of putative olfactory receptors
2
.
In vivo
calcium imaging showed that IR64a+ neurons projecting to the DC4 glomerulus in the antennal lobe are specifically activated by acids. Flies in which the function of IR64a+ neurons or the
IR64a
gene is disrupted had defects in acid-evoked physiological and behavioural responses, but their responses to non-acidic odorants remained unaffected. Furthermore, artificial stimulation of IR64a+ neurons elicited avoidance responses. Taken together, these results identify cellular and molecular substrates for acid detection in the
Drosophila
olfactory system and support a labelled-line mode of acidity coding at the periphery.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 631/208
/ Acidity
/ Acids
/ Animals
/ Arthropod Antennae - anatomy & histology
/ Arthropod Antennae - cytology
/ Arthropod Antennae - drug effects
/ Arthropod Antennae - innervation
/ Calcium Signaling - drug effects
/ Carbonic Acid - pharmacology
/ Drosophila melanogaster - anatomy & histology
/ Drosophila melanogaster - cytology
/ Drosophila melanogaster - drug effects
/ Drosophila melanogaster - physiology
/ Drosophila Proteins - metabolism
/ Humanities and Social Sciences
/ Insects
/ letter
/ Neurons
/ Odors
/ Olfactory Pathways - cytology
/ Olfactory Pathways - drug effects
/ Olfactory Pathways - physiology
/ Receptors, Ionotropic Glutamate
/ Receptors, Ionotropic Glutamate - metabolism
/ Receptors, Odorant - metabolism
/ Science
/ Sensilla
/ Sensory Receptor Cells - drug effects
