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Detection of classical BSE prions in asymptomatic cows after inoculation with atypical/Nor98 scrapie

by Douet, Jean‐yves , Bolea, Rosa , Instituto Agroalimentario de Aragón (IA2) ; Universidad de Zaragoza = University of Zaragoza [Saragossa University] = Université de Saragosse-Centro de Investigación y Tecnología Agroalimentaria de Aragón (CITA) , Universidad de Zaragoza = University of Zaragoza [Saragossa University] = Université de Saragosse , Huor, Alvina , Servicio de Cirugía y Medicina Equina, Hospital Veterinario ; Universidad de Zaragoza = University of Zaragoza [Saragossa University] = Université de Saragosse , Badiola, Juan, José , Romero, Antonio , Hedman, Carlos , Betancor, Marina , Interactions hôtes-agents pathogènes [Toulouse] (IHAP) ; Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

in Analysis / Animal biology / Animals / Antibodies / atypical scrapie / Beef cattle / Bovine spongiform encephalopathy / Brain / Cattle / Disease / Disease transmission / Immunohistochemistry / Immunology / Life Sciences / Medicine / Medicine & Public Health / Microbiology / Molecular weight / Prion / Prions / Propagation / Proteins / PrPSc / rodents / Scrapie / Seeds / Sheep / Short Report / swine / Veterinary medicine and animal Health / Veterinary Medicine/Veterinary Science / Virology

2023

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Detection of classical BSE prions in asymptomatic cows after inoculation with atypical/Nor98 scrapie

2023

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Detection of classical BSE prions in asymptomatic cows after inoculation with atypical/Nor98 scrapie

2023

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Journal Article

Detection of classical BSE prions in asymptomatic cows after inoculation with atypical/Nor98 scrapie

Douet, Jean‐yves,

Bolea, Rosa,

Instituto Agroalimentario de Aragón (IA2) ; Universidad de Zaragoza = University of Zaragoza [Saragossa University] = Université de Saragosse-Centro de Investigación y Tecnología Agroalimentaria de Aragón (CITA),

Universidad de Zaragoza = University of Zaragoza [Saragossa University] = Université de Saragosse,

Huor, Alvina,

Servicio de Cirugía y Medicina Equina, Hospital Veterinario ; Universidad de Zaragoza = University of Zaragoza [Saragossa University] = Université de Saragosse,

Badiola, Juan, José,

Romero, Antonio,

Hedman, Carlos,

Betancor, Marina,

Interactions hôtes-agents pathogènes [Toulouse] (IHAP) ; Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

2023

Overview

The emergence of bovine spongiform encephalopathy (BSE) prions from atypical scrapie has been recently observed upon experimental transmission to rodent and swine models. This study aimed to assess whether the inoculation of atypical scrapie could induce BSE-like disease in cattle. Four calves were intracerebrally challenged with atypical scrapie. Animals were euthanized without clinical signs of prion disease and tested negative for PrP Sc accumulation by immunohistochemistry and western blotting. However, an emergence of BSE-like prion seeding activity was detected during in vitro propagation of brain samples from the inoculated animals. These findings suggest that atypical scrapie may represent a potential source of BSE infection in cattle.

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Publisher

CCSD,BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC

Subject

/ Animals

/ Bovine spongiform encephalopathy