Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

by Van Wagoner, David R , Smith, J Gustav , Gollob, Michael H , Wakili, Reza , Steinbeck, Gerhard , Kao, W H Linda , Ellinor, Patrick T , Gudnason, Vilmundur , Ritchie, Marylyn D , Lohman, Kurt , Rotter, Jerome I , Smith, Nicholas L , McKnight, Barbara , Rienstra, Michiel , Harris, Tamara B , Pfeufer, Arne , Kubo, Michiaki , Soliman, Elsayed Z , Nakamura, Yusuke , Ridker, Paul M , Lubitz, Steven A , Borkovich, Matthew , Tsunoda, Tatsuhiko , Rivadeneira, Fernando , Völker, Uwe , Xu, Siyan , Melander, Olle , Chasman, Daniel I , Liu, Yongmei , Muhammad, Raafia , Felix, Stephan B , Rosand, Jonathan , Dörr, Marcus , Glazer, Nicole L , Krijthe, Bouwe P , Newman, Anne B , Parvez, Babar , Benjamin, Emelia J , Kamatani, Naoyuki , Darbar, Dawood , Barnard, John , Milan, David J , Sinner, Moritz F , Bis, Joshua C , Li, Guo , Perz, Siegfried , Rice, Kenneth M , Kathiresan, Sekar , Sjögren, Marketa , Alonso, Alvaro , Chen, Lin Y , Mahida, Saagar , Witteman, Jacqueline C M , Uitterlinden, Andre G , Furie, Karen L , Kääb, Stefan , Roden, Dan M , Völzke, Henry , Davies, Robert W , Hofman, Albert , Arking, Dan E , Stricker, Bruno H Ch , Clauss, Sebastian , Furukawa, Tetsushi , Meitinger, Thoma

in 631/208/205/2138 / 631/208/2489/144 / 631/443/592/75 / Adolescent / Adult / Aged / Aged, 80 and over / Agriculture / Animal Genetics and Genomics / Asian People - genetics / Atrial fibrillation / Atrial Fibrillation - genetics / Biological and medical sciences / Biomedical and Life Sciences / Biomedicine / Cancer Research / Cardiac arrhythmia / Cardiac dysrhythmias / Cardiology and Cardiovascular Disease / Cardiology. Vascular system / Child / Child, Preschool / Chromosomes / Clinical Medicine / Disease susceptibility / Female / Fundamental and applied biological sciences. Psychology / Gene Function / Gene loci / Gene mutations / Genealogy / Genetic aspects / Genetic Loci / Genetic Predisposition to Disease - genetics / Genetics / Genetics of eukaryotes. Biological and molecular evolution / Genome-Wide Association Study / Genomes / Health aspects / Heart / Human Genetics / Humans / Infant / Infant, Newborn / Kardiologi och kardiovaskulära sjukdomar / Klinisk medicin / letter / Male / Medical and Health Sciences / Medical sciences / Medicin och hälsovetenskap / Meta-analysis / Methods / Middle Aged / Musculoskeletal system / Mutation / Polymorphism, Single Nucleotide / Risk Factors / Signal transduction / White People - genetics / Young Adult

2012

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

2012

Confirm

Do you wish to request the book?

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

2012

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

Van Wagoner, David R,

Smith, J Gustav,

Gollob, Michael H,

Wakili, Reza,

Steinbeck, Gerhard,

Kao, W H Linda,

Ellinor, Patrick T,

Gudnason, Vilmundur,

Ritchie, Marylyn D,

Lohman, Kurt,

Rotter, Jerome I,

Smith, Nicholas L,

McKnight, Barbara,

Rienstra, Michiel,

Harris, Tamara B,

Pfeufer, Arne,

Kubo, Michiaki,

Soliman, Elsayed Z,

Nakamura, Yusuke,

Ridker, Paul M,

Lubitz, Steven A,

Borkovich, Matthew,

Tsunoda, Tatsuhiko,

Rivadeneira, Fernando,

Völker, Uwe,

Xu, Siyan,

Melander, Olle,

Chasman, Daniel I,

Liu, Yongmei,

Muhammad, Raafia,

Felix, Stephan B,

Rosand, Jonathan,

Dörr, Marcus,

Glazer, Nicole L,

Krijthe, Bouwe P,

Newman, Anne B,

Parvez, Babar,

Benjamin, Emelia J,

Kamatani, Naoyuki,

Darbar, Dawood,

Barnard, John,

Milan, David J,

Sinner, Moritz F,

Bis, Joshua C,

Li, Guo,

Perz, Siegfried,

Rice, Kenneth M,

Kathiresan, Sekar,

Sjögren, Marketa,

Alonso, Alvaro,

Chen, Lin Y,

Mahida, Saagar,

Witteman, Jacqueline C M,

Uitterlinden, Andre G,

Furie, Karen L,

Kääb, Stefan,

Roden, Dan M,

Völzke, Henry,

Davies, Robert W,

Hofman, Albert,

Arking, Dan E,

Stricker, Bruno H Ch,

Clauss, Sebastian,

Furukawa, Tetsushi,

Meitinger, Thoma

2012

Overview

Patrick Ellinor and colleagues report a meta-analysis of genome-wide association studies for atrial fibrillation in European populations. They identify six newly associated loci, four of which were replicated in a Japanese study. Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death 1 . We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation ( P < 5 × 10 −8 ). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

/ Adult

/ Aged

/ Aged, 80 and over