Journal Article

Additive Effect between IL-13 Polymorphism and Cesarean Section Delivery/Prenatal Antibiotics Use on Atopic Dermatitis: A Birth Cohort Study (COCOA)

Seo, Ju-hee, Kim, Hyo-Bin, Kang, Mi-Jin, Shin, Youn Ho, Hong, Seo Ah, Lee, Kyung-Ju, Kim, Kyung Won, Lee, So-Yeon, Jung, Young-ho, Park, Hee Jin, Lee, Soo-Young, Kim, Byoung-Ju, Kwon, Ji-Won, Won, Hye-Sung, Hong, Soo-Jong, Yu, Jinho, Song, Dae Jin, Yang, Song-I, Yoo, Ho-Sung, Shim, Jung Yeon, Kwon, Ja-Young, Ahn, Kang-Mo, Kim, Woo-Kyung, Lee, Kyung-shin, Lee, Eun, Jang, Gwang Cheon, Choi, Suk-Joo, Kim, Hyung-Young

2014

Overview

Although cesarean delivery and prenatal exposure to antibiotics are likely to affect the gut microbiome in infancy, their effect on the development of atopic dermatitis (AD) in infancy is unclear. The influence of individual genotypes on these relationships is also unclear. To evaluate with a prospective birth cohort study whether cesarean section, prenatal exposure to antibiotics, and susceptible genotypes act additively to promote the development of AD in infancy. The Cohort for Childhood of Asthma and Allergic Diseases (COCOA) was selected from the general Korean population. A pediatric allergist assessed 412 infants for the presence of AD at 1 year of age. Their cord blood DNA was subjected to interleukin (IL)-13 (rs20541) and cluster-of-differentiation (CD)14 (rs2569190) genotype analysis. The combination of cesarean delivery and prenatal exposure to antibiotics associated significantly and positively with AD (adjusted odds ratio, 5.70; 95% CI, 1.19-27.3). The association between cesarean delivery and AD was significantly modified by parental history of allergic diseases or risk-associated IL-13 (rs20541) and CD14 (rs2569190) genotypes. There was a trend of interaction between IL-13 (rs20541) and delivery mode with respect to the subsequent risk of AD. (P for interaction = 0.039) Infants who were exposed prenatally to antibiotics and were born by cesarean delivery had a lower total microbiota diversity in stool samples at 6 months of age than the control group. As the number of these risk factors increased, the AD risk rose (trend p<0.05). Cesarean delivery and prenatal antibiotic exposure may affect the gut microbiota, which may in turn influence the risk of AD in infants. These relationships may be shaped by the genetic predisposition.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adult / Allergic diseases / Analysis / Anti-Bacterial Agents - adverse effects / Anti-Bacterial Agents - therapeutic use / Antibiotics / Asthma / Atopic dermatitis / Biology and Life Sciences / CD14 antigen / Cesarean Section / Children / Cocoa / Cohort analysis / Cord blood / Cytokines / Deoxyribonucleic acid / Dermatitis / Dermatitis, Atopic - chemically induced / Dermatitis, Atopic - genetics / DNA / Eczema / Exposure / Female / Food allergies / Gene polymorphism / Gene-Environment Interaction / Genetic aspects / Genetic Association Studies / Genetic Predisposition to Disease / Genotypes / Gynecology / Health risks / Hospitals / Humans / Immune system / Infant / Infants / Interleukin / Interleukin 13 / Interleukin-13 - genetics / Interleukins / Intestinal microflora / Life sciences / Lipopolysaccharide Receptors - genetics / Male / Medicine / Medicine and Health Sciences / Microbiomes / Microbiota / Microbiota (Symbiotic organisms) / Obstetrics / Pediatrics / Physicians / Polymorphism / Polymorphism, Single Nucleotide / Pregnancy / Pregnant women / Prenatal experience / Prenatal exposure / Prenatal Exposure Delayed Effects - chemically induced / Prenatal Exposure Delayed Effects - genetics / Research and Analysis Methods / Risk / Risk analysis / Risk factors / Signal transduction / Studies / Tumor necrosis factor-TNF