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Visualizing a protein quake with time-resolved X-ray scattering at a free-electron laser

by Weierstall, Uwe , Chapman, Henry N , James, Daniel , Sjöhamn, Jennie , Bogan, Mike , Spence, John C H , Fromme, Petra , Kjær, Kasper Skov , Davidsson, Jan , Groenhof, Gerrit , Shoeman, Robert L , Neutze, Richard , van Driel, Tim Brandt , Stellato, Francesco , Milathianaki, Despina , Bari, Sadia , DePonte, Daniel P , Wang, Dingjie , Williams, Garth J , White, Thomas A , Henning, Robert , Seibert, M Marvin , Grotjohann, Ingo , Schlichting, Ilme , Westenhoff, Sebastian , Liang, Mengning , Arnlund, David , Katona, Gergely , Kosheleva, Irina , Aquila, Andrew , Hunter, Mark S , Kirian, Richard A , Messerschmidt, Marc , Wickstrand, Cecilia , Frank, Matthias , Kupitz, Christopher , Barty, Anton , Malmerberg, Erik , Berntsen, Peter , Zatsepin, Nadia A , Doak, R Bruce , Nielsen, Martin Meedom , Boutet, Sébastien , Fromme, Raimund , Martin, Andrew V , Johansson, Linda C

in 631/1647/2204 / 631/45/612/1237 / 631/57/2272 / 82/83 / Bacterial proteins / Biochemical Research Methods / Bioinformatics / Biological Microscopy / Biological Techniques / Biomedical Engineering/Biotechnology / brief-communication / Chemical Sciences / Crystal structure / Energy Transfer - radiation effects / Free electron lasers / FREQUENCY VIBRATIONAL-MODES / Kemi / Lasers / Life Sciences / Photosynthesis / Phycobiliproteins - chemistry / Phycobiliproteins - radiation effects / Phycobiliproteins - ultrastructure / Protein Conformation - radiation effects / Proteins / Proteomics / Radiation Dosage / Scattering, Small Angle / STRUCTURAL DYNAMICS / Structure / X-ray crystallography / X-Ray Diffraction - methods

2014

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Visualizing a protein quake with time-resolved X-ray scattering at a free-electron laser

2014

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Visualizing a protein quake with time-resolved X-ray scattering at a free-electron laser

2014

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Journal Article

Visualizing a protein quake with time-resolved X-ray scattering at a free-electron laser

Weierstall, Uwe,

Chapman, Henry N,

James, Daniel,

Sjöhamn, Jennie,

Bogan, Mike,

Spence, John C H,

Fromme, Petra,

Kjær, Kasper Skov,

Davidsson, Jan,

Groenhof, Gerrit,

Shoeman, Robert L,

Neutze, Richard,

van Driel, Tim Brandt,

Stellato, Francesco,

Milathianaki, Despina,

Bari, Sadia,

DePonte, Daniel P,

Wang, Dingjie,

Williams, Garth J,

White, Thomas A,

Henning, Robert,

Seibert, M Marvin,

Grotjohann, Ingo,

Schlichting, Ilme,

Westenhoff, Sebastian,

Liang, Mengning,

Arnlund, David,

Katona, Gergely,

Kosheleva, Irina,

Aquila, Andrew,

Hunter, Mark S,

Kirian, Richard A,

Messerschmidt, Marc,

Wickstrand, Cecilia,

Frank, Matthias,

Kupitz, Christopher,

Barty, Anton,

Malmerberg, Erik,

Berntsen, Peter,

Zatsepin, Nadia A,

Doak, R Bruce,

Nielsen, Martin Meedom,

Boutet, Sébastien,

Fromme, Raimund,

Martin, Andrew V,

Johansson, Linda C

2014

Overview

A 'protein quake' is directly monitored on the picosecond timescale using the method of time-resolved wide-angle X-ray scattering at an X-ray free-electron laser. We describe a method to measure ultrafast protein structural changes using time-resolved wide-angle X-ray scattering at an X-ray free-electron laser. We demonstrated this approach using multiphoton excitation of the Blastochloris viridis photosynthetic reaction center, observing an ultrafast global conformational change that arises within picoseconds and precedes the propagation of heat through the protein. This provides direct structural evidence for a 'protein quake': the hypothesis that proteins rapidly dissipate energy through quake-like structural motions.

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Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

/ 82/83

/ Biochemical Research Methods

/ Bioinformatics