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Piezo2 is the principal mechanotransduction channel for proprioception
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Journal Article
Piezo2 is the principal mechanotransduction channel for proprioception
2015
Overview
Proprioception, the sense of body and limb position, begins in nerve cells called proprioceptors that are activated by muscle or joint stretch. The molecular mechanism of mechanotransduction in mammalian proprioceptors is unknown. The authors show that the mechanically activated cation channel Piezo2 is the principal mechanotransducer in murine proprioceptors.
Proprioception, the perception of body and limb position, is mediated by proprioceptors, specialized mechanosensory neurons that convey information about the stretch and tension experienced by muscles, tendons, skin and joints. In mammals, the molecular identity of the stretch-sensitive channel that mediates proprioception is unknown. We found that the mechanically activated nonselective cation channel Piezo2 was expressed in sensory endings of proprioceptors innervating muscle spindles and Golgi tendon organs in mice. Two independent mouse lines that lack Piezo2 in proprioceptive neurons showed severely uncoordinated body movements and abnormal limb positions. Moreover, the mechanosensitivity of parvalbumin-expressing neurons that predominantly mark proprioceptors was dependent on Piezo2 expression
in vitro
, and the stretch-induced firing of proprioceptors in muscle-nerve recordings was markedly reduced in Piezo2-deficient mice. Together, our results indicate that Piezo2 is the major mechanotransducer of mammalian proprioceptors.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 13/1
/ 13/106
/ 14/19
/ 38/32
/ 38/90
/ 64
/ 64/110
/ 9/74
/ Animal Genetics and Genomics
/ Animals
/ Cellular signal transduction
/ Female
/ Ganglia, Spinal - physiology
/ Insects
/ Male
/ Mechanotransduction, Cellular - physiology
/ Mice
/ Movement Disorders - genetics
/ Movement Disorders - metabolism
