Journal Article

Candida auris: A rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally

Chowdhary, Anuradha, Sharma, Cheshta, Meis, Jacques F.

2017

Overview

About the Authors: Anuradha Chowdhary * E-mail: [e-mail] Affiliation: Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India ORCID http://orcid.org/0000-0002-2028-7462 Cheshta Sharma Affiliation: Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India Jacques F. Meis Affiliations Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands, Centre of Expertise in Mycology Radboudumc/CWZ, Nijmegen, the Netherlands ORCID http://orcid.org/0000-0003-3253-6080Citation: Chowdhary A, Sharma C, Meis JF (2017) Candida auris: A rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally. The species exhibits a close phylogenetic relationship to C. haemulonii and is differentiated based on sequence analysis of the D1/D2 domain of the large ribosomal subunit (LSU) of 26S rRNA gene and the internal transcribed spacer (ITS) regions of the nuclear rRNA gene operon [23]. [...]Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) is considered a more rapid and robust diagnostic technique for C. auris identification [9, 10, 13, 16]. Worldwide reports of Candida auris along with their misidentification using commercial systems and frequency of antifungal resistance. https://doi.org/10.1371/journal.ppat.1006290.t001 Does genetic predisposition make C. auris virulent? A recently published draft genome of C. auris shows that it has a genome size of approximately 12.3 Mb [26, 27]. The emerging Candida auris: characterization of growth phenotype, virulence factors, antifungal activity, and effect of SCY-078, a novel glucan synthesis inhibitor, on growth morphology and biofilm formation. Identification and typing of the emerging pathogen Candida auris by matrix-assisted laser desorption ionisation time of flight mass spectrometry...

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Animals / Antifungal activity / Biofilms / Biology and Life Sciences / Candida / Candida - genetics / Candida - pathogenicity / Candidiasis / Candidiasis - diagnosis / Candidiasis - microbiology / Candidiasis - transmission / Causes of / Chest / Cross Infection / Desorption / Development and progression / Diagnostic systems / Distribution / Drug resistance / Drug Resistance, Multiple, Fungal / Fungal infections / Fungi / Fungicides / Genetic aspects / Genomes / Glucan / Hospitals / Humans / Iatrogenic Disease - epidemiology / Identification systems / Infectious diseases / Ionization / Laboratories / Mail / Mass spectrometry / Mass spectroscopy / Medicine and Health Sciences / Microbiology / Multidrug resistance / Multidrug resistant organisms / Multilocus sequence typing / Mycology / Pathogens / Pearls / Phylogeny / Physical Sciences / Physiological aspects / Research and Analysis Methods / rRNA / rRNA 26S / Scholarships & fellowships / Scientific imaging / Spacer / Spectroscopy / Virulence / Virulence factors / Yeast