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Enhancing bacterial survival through phenotypic heterogeneity
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Journal Article
Enhancing bacterial survival through phenotypic heterogeneity
2020
Overview
Variations in the number of nucleotides within an SSR in a coding sequence may cause a frameshift mutation that creates a premature stop codon and a truncated product (OFF) or, conversely, may restore the reading frame and production of the gene product (ON). [...]phase variation can be achieved by shuffling alleles of the same gene between an expressed locus and a distal, silent locus. Consistent with this result, phase-locked OFF mutants lacking fimbriae are attenuated in disease models of urinary tract infection [12, 13]. Some DNA methyltransferases, enzymes that methylate specific nucleotide motifs, are subject to phase variation, resulting in a population of bacteria with different methylation patterns. Because methylation can influence gene expression, methyltransferase phase variation can influence the transcription of multiple genes simultaneously.
Publisher
Public Library of Science,Public Library of Science (PLoS)
