Journal Article

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Eriksson, Johan G, Spector, Timothy D, Lawrence, Robert W, Coin, Lachlan, Mohlke, Karen L, Duan, Jubao, Purcell, Shaun, Luan, Jian'an, Welch, Ryan, Freimer, Nelson B, Ridderstråle, Martin, Stringham, Heather M, Jewell, Elizabeth, Lantieri, Olivier, McKnight, Barbara, Beilby, John P, Sanna, Serena, Harris, Tamara B, Pedersen, Oluf, Elosua, Roberto, Walters, G Bragi, Amin, Najaf, Swift, Amy J, Jørgensen, Torben, Kettunen, Johannes, Hayes, Richard B, Hveem, Kristian, Hicks, Andrew A, Munroe, Patricia B, Ebrahim, Shah, Midthjell, Kristian, Hengstenberg, Christian, Witte, Daniel R, Zgaga, Lina, Elliott, Paul, Eiriksdottir, Gudny, Guiducci, Candace, Randall, Joshua C, Peters, Annette, Geus, Eco J C, Strachan, David P, Winkler, Thomas W, Kaprio, Jaakko, König, Inke R, Kaakinen, Marika, Cooper, Matthew N, Cavalcanti-Proença, Christine, Ketkar, Shamika, Speliotes, Elizabeth K, Qi, Lu, Robertson, Neil R, Hu, Frank B, Kvaløy, Kirsti, Campbell, Harry, Sandhu, Manjinder S, Bouatia-Naji, Nabila, Groves, Christopher J, Tönjes, Anke, Narisu, Narisu, Barroso, Inês, Waeber, Gérard, Alavere, Helene, Loos, Ruth J F, Boerwinkle,

2010

Overview

Ruth Loos and colleagues report results of a large genome-wide association study for body mass index. They identify 18 new loci associated with this trait, some of which map near key hypothalamic regulators of energy balance. Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index ( P < 5 × 10 −8 ), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R , POMC , SH2B1 and BDNF ) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR , an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

• Publisher: Nature Publishing Group US,Nature Publishing Group
• Subject: 631/208/205/2138 / 631/208/727/2000 / 692/699/2743/393 / 692/700/139/1735 / Agriculture / Animal Genetics and Genomics / Biological and medical sciences / Biomedical and Life Sciences / Biomedical research / Biomedicine / Body Height - genetics / Body Mass Index / Body Size - genetics / Body weight / Body Weight - genetics / Cancer Research / Cardiology and Cardiovascular Disease / Charitable foundations / Chromosome Mapping / Clinical Medicine / Councils / Endocrinology and Diabetes / Endokrinologi och diabetes / Energy balance / Fundamental and applied biological sciences. Psychology / Fysiologi och anatomi / Gene Function / Genetic aspects / Genetic factors / Genetic Predisposition to Disease - genetics / Genetics / Genetics of eukaryotes. Biological and molecular evolution / Genome-Wide Association Study / Health Sciences / Hospitals / Human Genetics / Humans / Hälsovetenskap / Kardiologi och kardiovaskulära sjukdomar / Klinisk medicin / Measurement / Medical and Health Sciences / Medical research / MEDICIN / Medicin och hälsovetenskap / MEDICINE / Nutrition and Dietetics / Näringslära och dietkunskap / Obesity / Obesity - genetics / Physiology and Anatomy / Polymorphism, Single Nucleotide / Public health / Risk assessment / Risk factors / Studies / White People - genetics