Journal Article

Association between History of Dental Amalgam Fillings and Risk of Parkinson’s Disease: A Population-Based Retrospective Cohort Study in Taiwan

Lee, Hsin-Lin, Chiu, Hsien-Chung, Chang, Cheng-Wei, Horng, Jorng-Tzong, Chuang, Chuan-Chung, Hsu, Yung-Chuang, Li, Wan-Yun, Fu, Earl

2016

Overview

The impact of dental amalgam on the development of Parkinson's disease (PD) is still uncertain, although a positive association between dental amalgam and PD has been found in a few case-control studies. The patients with amalgam fillings restored between 2000 and 2008 were identified by using the National Health Insurance Research Database (NHIRD) in Taiwan. The same number of patients who had no new amalgam filling restored was matched by sex, age, and treatment date. Both cohorts were followed up from the treatment date until the date of diagnosis of PD, death, or the end of the year 2008. The individuals who received amalgam fillings had a significantly higher risk of PD afterward (adjusted hazard ratio [HR]=1.583, 95% confidence interval [CI]=1.122-2.234, p=0.0089) than those who did not. In the individuals who received amalgam fillings, being diagnosed with diabetes or hyperlipidemia demonstrated a significantly lower HR of PD occurrence than in the patients without diabetes or hyperlipidemia (HR=0.449, 95% CI=0.254-0.794, p=0.0059; HR=0.445, 95% CI=0.260-0.763, p=0.0032) after adjusting for comorbidities and Charlson-Deyo Comorbidity Index (CCI) scores. Meanwhile, hypertension increased the hazard risk of PD (HR=1.645, 95% CI=1.098-2.464, p=0.0159). The patients exposed to dental amalgam fillings were 1.583 times more likely to have PD afterward compared to their non-exposed counterparts after adjusting for comorbidities and CCI scores.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adult / Age / Aged / Alzheimer's disease / Case-Control Studies / Cohort analysis / Complications and side effects / Computer science / Confidence intervals / Dental Amalgam - adverse effects / Dental Amalgam - therapeutic use / Dental Amalgam - toxicity / Dental amalgams / Dental caries / Dental restorative materials / Dentistry / Diabetes / Diabetes mellitus / Epidemiology / Female / Gene expression / Head injuries / Health aspects / Health risks / Hospitals / Humans / Hyperlipidemia / Hypertension / Informatics / Kinases / Male / Medical diagnosis / Medicine and Health Sciences / Mercury - adverse effects / Mercury - therapeutic use / Metabolism / Middle Aged / Movement disorders / Neurodegenerative diseases / Older people / Online databases / Oxidative stress / Parkinson disease / Parkinson Disease, Secondary - chemically induced / Parkinson Disease, Secondary - epidemiology / Parkinson Disease, Secondary - pathology / Parkinson's disease / Patients / Physical Sciences / Population / Population studies / Population-based studies / Proportional Hazards Models / Risk / Risk Factors / Studies / Taiwan