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THPdb: Database of FDA-approved peptide and protein therapeutics

by Usmani, Salman Sadullah , Gautam, Ankur , Kalra, Sourav , Kumar, Pawan , Sharma, Meenu , Samuel, Jesse S. , Singh, Sandeep , Bedi, Gursimran , Ahuja, Anjuman Arora , Raghava, Gajendra P. S.

in Applications programs / Bioavailability / Bioinformatics / Biology and Life Sciences / Browsing / Chemical composition / Chemical properties / Data analysis / Data processing / Databases, Protein / Documents / Drug approval / Internet / Medicine and Health Sciences / Mobile Applications / Mobile computing / Peptides / Peptides - chemistry / Peptides - therapeutic use / Pharmaceuticals / Pharmacodynamics / Pharmacology / Programming Languages / Proteins / Proteins - chemistry / Proteins - therapeutic use / Regulatory agencies / Research and Analysis Methods / Software / Therapeutics / Toxicity / United States / United States Food and Drug Administration / User-Computer Interface

2017

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THPdb: Database of FDA-approved peptide and protein therapeutics

by Usmani, Salman Sadullah , Gautam, Ankur , Kalra, Sourav , Kumar, Pawan , Sharma, Meenu , Samuel, Jesse S. , Singh, Sandeep , Bedi, Gursimran , Ahuja, Anjuman Arora , Raghava, Gajendra P. S.

2017

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THPdb: Database of FDA-approved peptide and protein therapeutics

by Usmani, Salman Sadullah , Gautam, Ankur , Kalra, Sourav , Kumar, Pawan , Sharma, Meenu , Samuel, Jesse S. , Singh, Sandeep , Bedi, Gursimran , Ahuja, Anjuman Arora , Raghava, Gajendra P. S.

2017

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Journal Article

THPdb: Database of FDA-approved peptide and protein therapeutics

Usmani, Salman Sadullah,

Gautam, Ankur,

Kalra, Sourav,

Kumar, Pawan,

Sharma, Meenu,

Samuel, Jesse S.,

Singh, Sandeep,

Bedi, Gursimran,

Ahuja, Anjuman Arora,

Raghava, Gajendra P. S.

2017

Overview

THPdb (http://crdd.osdd.net/raghava/thpdb/) is a manually curated repository of Food and Drug Administration (FDA) approved therapeutic peptides and proteins. The information in THPdb has been compiled from 985 research publications, 70 patents and other resources like DrugBank. The current version of the database holds a total of 852 entries, providing comprehensive information on 239 US-FDA approved therapeutic peptides and proteins and their 380 drug variants. The information on each peptide and protein includes their sequences, chemical properties, composition, disease area, mode of activity, physical appearance, category or pharmacological class, pharmacodynamics, route of administration, toxicity, target of activity, etc. In addition, we have annotated the structure of most of the protein and peptides. A number of user-friendly tools have been integrated to facilitate easy browsing and data analysis. To assist scientific community, a web interface and mobile App have also been developed.

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Publisher

Public Library of Science,Public Library of Science (PLoS)

Subject

Applications programs

/ Bioavailability

/ Bioinformatics

/ Biology and Life Sciences

/ Browsing

/ Chemical composition

/ Chemical properties