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Specific Lipopolysaccharide Found in Cystic Fibrosis Airway Pseudomonas aeruginosa
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Specific Lipopolysaccharide Found in Cystic Fibrosis Airway Pseudomonas aeruginosa
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Journal Article
Specific Lipopolysaccharide Found in Cystic Fibrosis Airway Pseudomonas aeruginosa
1999
Overview
Cystic fibrosis (CF) patients develop chronic airway infections with Pseudomonas aeruginosa (PA). Pseudomonas aeruginosa synthesized lipopolysaccharide (LPS) with a variety of penta- and hexa-acylated lipid A structures under different environmental conditions. CF patient PA synthesized LPS with specific lipid A structures indicating unique recognition of the CF airway environment. CF-specific lipid A forms containing palmitate and aminoarabinose were associated with resistance to cationic antimicrobial peptides and increased inflammatory responses, indicating that they are likely to be involved in airway disease.
Publisher
American Society for the Advancement of Science,American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Arabinose - analogs & derivatives
/ Bacterial diseases of the respiratory system
/ Bacterial Proteins - genetics
/ Bacterial Proteins - physiology
/ Biological and medical sciences
/ Blood
/ Cystic Fibrosis - complications
/ Cystic Fibrosis - microbiology
/ Humans
/ Infant
/ Interleukin-8 - biosynthesis
/ Lipids
/ Lipopolysaccharides - chemistry
/ Lipopolysaccharides - immunology
/ Mutation
/ Patients
/ Pseudomonas aeruginosa - drug effects
/ Pseudomonas aeruginosa - genetics
/ Pseudomonas aeruginosa - metabolism
/ Pseudomonas aeruginosa - pathogenicity
/ Pseudomonas Infections - microbiology
/ Respiratory System - microbiology
/ Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
